Psychoactive substances with chemical structures or pharmacological profiles that are
similar to traditional drugs of abuse continue to emerge on the recreational drug market …

Succinate is an important metabolite at the cross-road of several metabolic pathways, also
involved in the formation and elimination of reactive oxygen species. However, it is …

The illicit recreational drug of abuse, γ-hydroxybutyrate (GHB) is a potent central nervous
system depressant and is often encountered during forensic investigations of living and …

GABAB receptors (GABABRs) are G protein-coupled receptors for GABA, the main inhibitory
neurotransmitter in the CNS. In the past 5 years, notable advances have been made in our …

This review assesses the parallel data on the role of gamma‐aminobutyric acid (GABA) in
depression and anxiety. We review historical and new data from both animal and human …

Synaptic regulation of the primary inhibitory neurotransmitter γ-aminobutyric acid (GABA) is
essential for brain function. Cerebral GABA homeostasis is tightly regulated through multiple …

Agonists of GABAB receptors exert a bi-directional effect on the activity of dopamine (DA)
neurons of the ventral tegmental area, which can be explained by the fact that coupling …

GABAB receptors are the G-protein coupled receptors for the main inhibitory
neurotransmitter in the brain, γ-aminobutyric acid (GABA). While native studies predicted …

GHB is used therapeutically and recreationally, although the precise mechanism of action
responsible for its different behavioral effects is not entirely clear. The purpose of this review …

This chapter presents new clinical applications of the prototypic GABA B receptor agonist
baclofen for the treatment of addiction by drugs of abuse, such as alcohol, cocaine, nicotine …