Gephyrin: a master regulator of neuronal function?
SK Tyagarajan, JM Fritschy - Nature Reviews Neuroscience, 2014 - nature.com
The neurotransmitters GABA and glycine mediate fast synaptic inhibition by activating ligand-
gated chloride channels—namely, type A GABA (GABAA) and glycine receptors. Both types …
gated chloride channels—namely, type A GABA (GABAA) and glycine receptors. Both types …
A pivotal role of GSK-3 in synaptic plasticity
Glycogen synthase kinase-3 (GSK-3) has many cellular functions. Recent evidence
suggests that it plays a key role in certain types of synaptic plasticity, in particular a form of …
suggests that it plays a key role in certain types of synaptic plasticity, in particular a form of …
Neurochemical modifications in the hippocampus, cortex and hypothalamus of mice exposed to long-term high-fat diet
Metabolic syndrome and diabetes impact brain function and metabolism. While it is well
established that rodents exposed to diets rich in saturated fat develop brain dysfunction …
established that rodents exposed to diets rich in saturated fat develop brain dysfunction …
Quantitative nanoscopy of inhibitory synapses: counting gephyrin molecules and receptor binding sites
CG Specht, I Izeddin, PC Rodriguez, M El Beheiry… - Neuron, 2013 - cell.com
The strength of synaptic transmission is controlled by the number and activity of
neurotransmitter receptors. However, little is known about absolute numbers and densities …
neurotransmitter receptors. However, little is known about absolute numbers and densities …
GARLH family proteins stabilize GABAA receptors at synapses
T Yamasaki, E Hoyos-Ramirez, JS Martenson… - Neuron, 2017 - cell.com
Ionotropic neurotransmitter receptors mediate fast synaptic transmission by functioning as
ligand-gated ion channels. Fast inhibitory transmission in the brain is mediated mostly by …
ligand-gated ion channels. Fast inhibitory transmission in the brain is mediated mostly by …
Fundamental Neurochemistry Review: GABAA receptor neurotransmission and epilepsy: Principles, disease mechanisms and pharmacotherapy
Epilepsy is a common neurological disorder associated with alterations of excitation‐
inhibition balance within brain neuronal networks. GABAA receptor neurotransmission is the …
inhibition balance within brain neuronal networks. GABAA receptor neurotransmission is the …
Gephyrin, the enigmatic organizer at GABAergic synapses
GABAA receptors are clustered at synaptic sites to achieve a high density of postsynaptic
receptors opposite the input axonal terminals. This allows for an efficient propagation of …
receptors opposite the input axonal terminals. This allows for an efficient propagation of …
Functional regulation of GABAA receptors in nervous system pathologies
Inhibitory neurotransmission is primarily governed by γ-aminobutyric acid (GABA) type A
receptors (GABAARs). GABAARs are heteropentameric ligand-gated channels formed by …
receptors (GABAARs). GABAARs are heteropentameric ligand-gated channels formed by …
Identification of a stereotypic molecular arrangement of endogenous glycine receptors at spinal cord synapses
SA Maynard, P Rostaing, N Schaefer, O Gemin… - Elife, 2021 - elifesciences.org
Precise quantitative information about the molecular architecture of synapses is essential to
understanding the functional specificity and downstream signaling processes at specific …
understanding the functional specificity and downstream signaling processes at specific …
GABAA receptor α and γ subunits shape synaptic currents via different mechanisms
Synaptic GABA A receptors (GABA A Rs) mediate most of the inhibitory neurotransmission in
the brain. The majority of these receptors are comprised of α1, β2, and γ2 subunits. The …
the brain. The majority of these receptors are comprised of α1, β2, and γ2 subunits. The …