Long non-coding RNAs: definitions, functions, challenges and recommendations
Genes specifying long non-coding RNAs (lncRNAs) occupy a large fraction of the genomes
of complex organisms. The term 'lncRNAs' encompasses RNA polymerase I (Pol I), Pol II …
of complex organisms. The term 'lncRNAs' encompasses RNA polymerase I (Pol I), Pol II …
How RNA-binding proteins interact with RNA: molecules and mechanisms
M Corley, MC Burns, GW Yeo - Molecular cell, 2020 - cell.com
RNA-binding proteins (RBPs) comprise a large class of over 2,000 proteins that interact with
transcripts in all manner of RNA-driven processes. The structures and mechanisms that …
transcripts in all manner of RNA-driven processes. The structures and mechanisms that …
OpenCell: Endogenous tagging for the cartography of human cellular organization
Elucidating the wiring diagram of the human cell is a central goal of the postgenomic era.
We combined genome engineering, confocal live-cell imaging, mass spectrometry, and data …
We combined genome engineering, confocal live-cell imaging, mass spectrometry, and data …
flDPnn: Accurate intrinsic disorder prediction with putative propensities of disorder functions
G Hu, A Katuwawala, K Wang, Z Wu… - Nature …, 2021 - nature.com
Identification of intrinsic disorder in proteins relies in large part on computational predictors,
which demands that their accuracy should be high. Since intrinsic disorder carries out a …
which demands that their accuracy should be high. Since intrinsic disorder carries out a …
Intrinsically disordered proteins: an overview
R Trivedi, HA Nagarajaram - International journal of molecular sciences, 2022 - mdpi.com
Many proteins and protein segments cannot attain a single stable three-dimensional
structure under physiological conditions; instead, they adopt multiple interconverting …
structure under physiological conditions; instead, they adopt multiple interconverting …
[HTML][HTML] Long non-coding RNA and RNA-binding protein interactions in cancer: experimental and machine learning approaches
Understanding the complex and specific roles played by non-coding RNAs (ncRNAs), which
comprise the bulk of the genome, is important for understanding virtually every hallmark of …
comprise the bulk of the genome, is important for understanding virtually every hallmark of …
Signal-noise metrics for RNA binding protein identification reveal broad spectrum protein-RNA interaction frequencies and dynamics
JC Kristofich, CV Nicchitta - Nature Communications, 2023 - nature.com
Recent efforts towards the comprehensive identification of RNA-bound proteomes have
revealed a large, surprisingly diverse family of candidate RNA-binding proteins (RBPs) …
revealed a large, surprisingly diverse family of candidate RNA-binding proteins (RBPs) …
Protein–DNA/RNA interactions: an overview of investigation methods in the-omics era
F Cozzolino, I Iacobucci, V Monaco… - Journal of Proteome …, 2021 - ACS Publications
The fields of application of functional proteomics are not limited to the study of protein–
protein interactions; they also extend to those involving protein complexes that bind DNA or …
protein interactions; they also extend to those involving protein complexes that bind DNA or …
The role of DEAD-box ATPases in gene expression and the regulation of RNA–protein condensates
DEAD-box ATPases constitute a very large protein family present in all cells, often in great
abundance. From bacteria to humans, they play critical roles in many aspects of RNA …
abundance. From bacteria to humans, they play critical roles in many aspects of RNA …