Cell type-and differentiation-specific gene expression is precisely controlled by genomic non-
coding regulatory elements (NCREs), which include promoters, enhancers, silencers and …

Gene regulatory elements, including promoters, enhancers, silencers, etc., control
transcriptional programs in a spatiotemporal manner. Though these elements are known to …

The retina is a light-sensitive highly-organized tissue, which is vulnerable to aging and age-
related retinal diseases. Specifically, progressive retinal degeneration leads to visual …

Elucidating the role of 3D architecture of DNA in gene regulation is crucial for understanding
cell differentiation, tissue homeostasis and disease development. Among various chromatin …

Dogs have become a valuable model in exploring multifaceted diseases and biology
relevant to human health. Despite large-scale dog genome projects producing high-quality …

The dog, Canis lupus familiaris, is an important model for studying human diseases. Unlike
many model organisms, the dog genome has a comparatively poor functional annotation …

Canine progressive retinal atrophy (PRA) describes a group of hereditary diseases
characterized by photoreceptor cell death in the retina, leading to visual impairment. Despite …

Two recent papers by Gustavo Aguirre's and Hannes Lohi's groups have been published
describing the genetics of Progressive Retinal Atrophy (PRA) in Miniature Schnauzers. This …

This thesis addresses the genetic background of five spontaneous canine models of rare
human disease. By utilizing genome-wide mapping methods, next-generation sequencing …

Dogs represent a fascinating species with dramatic variation in traits across hundreds of
breeds. Genetic bottlenecks, inbreeding, and selection for extreme phenotypes have led to …