Mitochondria are one of the most important organelles in cardiomyocytes. Mitochondrial
homeostasis is necessary for the maintenance of normal heart function. Mitochondria …

Cardiac excitation-contraction coupling requires dyads, the nanoscopic microdomains
formed adjacent to Z-lines by apposition of transverse tubules and junctional sarcoplasmic …

Cardiomyocytes derived from human induced pluripotent stem cells (hiPSC-CMs) lack
nanoscale structures essential for efficient excitation–contraction coupling. Such …

Understanding how the atrial and ventricular heart chambers maintain distinct identities is a
prerequisite for treating chamber-specific diseases. In this study, we selectively knocked out …

Aims Calcium-handling capacity is a major gauge of cardiomyocyte maturity. Ryanodine
receptor 2 (RYR2) is the pre-dominant calcium channel that releases calcium from the …

A method for characterizing and quantifying peaks formed in an analytical buoyant density
equilibrium (ABDE) experiment is presented. An algorithm is derived to calculate the …

Understanding how the atrial and ventricular chambers of the heart maintain their distinct
identity is a prerequisite for treating chamber-specific diseases. Here, we selectively …

Neonatal mouse hearts have transient renewal capacity, which is lost in juvenile and adult
stages. In neonatal mouse hearts, myocardial infarction (MI) causes an initial loss of …

Background Chronic alcohol intake is associated with an increased risk of alcoholic
cardiomyopathy, which may present with pathological changes such as myocardial insulin …

Cardiomyocyte differentiation continues throughout murine gestation and into the postnatal
period, driven by temporally regulated expression changes in the transcriptome. The …