Designing drug delivery systems for cell therapy

LLW Wang, Y Gao, Z Feng, DJ Mooney… - Nature Reviews …, 2024 - nature.com
Cell therapies, such as immune cell and stem cell therapies, are being preclinically and
clinically explored for the treatment of various diseases, but are often limited by low efficacy …

Bottom-up synthetic immunology

K Göpfrich, M Platten, F Frischknecht… - Nature …, 2024 - nature.com
Infectious diseases and cancer evade immune surveillance using similar mechanisms.
Targeting immune mechanisms using common strategies thus represents a promising …

Immune cell‐based microrobots for remote magnetic actuation, antitumor activity, and medical imaging

NO Dogan, E Suadiye, P Wrede… - Advanced …, 2024 - Wiley Online Library
Translating medical microrobots into clinics requires tracking, localization, and performing
assigned medical tasks at target locations, which can only happen when appropriate design …

Nano/genetically engineered cells for immunotherapy

J Shen, Y Zhou, L Yin - BMEMat, 2024 - Wiley Online Library
Immunotherapy has recently emerged as a promising therapeutic modality for the treatment
of various diseases such as cancer, inflammation, autoimmune diseases, and infectious …

An “Outer Piezoelectric and Inner Epigenetic” Logic‐Gated PANoptosis for Osteosarcoma Sono‐Immunotherapy and Bone Regeneration

X Wang, X Guo, H Ren, X Song, L Chen… - Advanced …, 2024 - Wiley Online Library
The precise manipulation of PANoptosis, a newly defined cell death pathway encompassing
pyroptosis, apoptosis, and necroptosis, is highly desired to achieve safer cancer …

[HTML][HTML] Nanoscale synthetic biology with innovative medicinal applications

J Ji, L Li, W Guo, J Zhang, Y Yao, H Chen, F Liao… - Fundamental …, 2024 - Elsevier
The rapid advancement of synthetic biology and nanoscience has given rise to a new
research field, known as nanoscale synthetic biology (NSB). This field emphasizes the …

Mechanoimmune-Driven Backpack Sustains Dendritic Cell Maturation for Synergistic Tumor Radiotherapy

H Yu, Z Liu, H Guo, X Hu, Y Wang, X Cheng… - ACS …, 2024 - ACS Publications
Cell backpacks present significant potential in both therapeutic and diagnostic applications,
making it essential to further explore their interactions with host cells. Current evidence …

Adaptations of neutrophils in cancer

M Ng, D Cerezo-Wallis, LG Ng, A Hidalgo - Immunity, 2025 - cell.com
There is a renewed interest in neutrophil biology, largely instigated by their prominence in
cancer. From an immunologist's perspective, a conceptual breakthrough is the realization …

Delivery Systems Developed for Treatment Combinations to Improve Adoptive Cell Therapy

F Xu, Q Ni, N Gong, B Xia, J Zhang, W Guo… - Advanced …, 2024 - Wiley Online Library
Adoptive cell therapy (ACT) has shown great success in the clinic for treating hematologic
malignancies. However, solid tumor treatment with ACT monotherapy is still challenging …

Living Biomaterials: Fabrication Strategies and Biomedical Applications

QW Chen, XZ Zhang - Accounts of Materials Research, 2024 - ACS Publications
Conspectus Natural or bioengineered living organisms (including mammalian cells,
bacteria, microalgaes, yeast, viruses, plant cells, and the multiple organism community) …