Schizophrenia is a worldwide mental illness characterized by alterations at dopaminergic
and glutamatergic synapses resulting in global dysconnectivity within and between brain …

Current pharmacological treatments for bipolar disorder are inadequate and based on
serendipitously discovered drugs often with limited efficacy, burdensome side-effects, and …

Dopamine-glutamate interplay dysfunctions have been suggested as pathophysiological
key determinants of major psychotic disorders, above all schizophrenia and mood disorders …

The repertoire of signal transduction pathways activated by dopamine in brain includes the
increase of intracellular calcium. However the mechanism (s) by which dopamine activated …

Clozapine is an antipsychotic drug that has a greater efficacy than other medications in
some contexts, especially for the treatment of treatment-resistant schizophrenia. However …

One of the remarkable discoveries in the field of psychopharmacology from late 1940s is
Lithium (Li) that reminds of old but still gold. It continues to be a distinctive mood stabilizer …

Mutations in the genes encoding calcium/calmodulin dependent protein kinase II (CAMK2)
isoforms cause a newly recognized neurodevelopmental disorder (ND), for which the full …

Affective deficits are one common denominator of schizophrenia (SZ), bipolar disorder (BD)
and obsessive compulsive disorder (OCD) with the amygdala indicated as one of the major …

We report the case of a 43 year old male with no prior psychiatric history with apparent
tacrolimus-induced psychosis. Previous reports have identified other neurotoxic adverse …

Tacrolimus, a potent posttransplant immunosuppressant, has been associated with major
neuropsychiatric complications, including catatonia and psychosis. We report a novel case …