Collagen binding proteins of gram-positive pathogens

S Arora, J Gordon, M Hook - Frontiers in Microbiology, 2021 - frontiersin.org
Collagens are the primary structural components of mammalian extracellular matrices. In
addition, collagens regulate tissue development, regeneration and host defense through …

The biosynthesis and structures of bacterial pili

M Lukaszczyk, B Pradhan, H Remaut - Bacterial cell walls and membranes, 2019 - Springer
To interact with the external environments, bacteria often display long proteinaceous
appendages on their cell surface, called pili or fimbriae. These non-flagellar thread-like …

Unmasking of the von Willebrand A-domain surface adhesin CglB at bacterial focal adhesions mediates myxobacterial gliding motility

ST Islam, NY Jolivet, C Cuzin, AM Belgrave, L My… - Science …, 2023 - science.org
The predatory deltaproteobacterium Myxococcus xanthus uses a helically-trafficked motor at
bacterial focal-adhesion (bFA) sites to power gliding motility. Using total internal reflection …

Identification of a group B streptococcal fibronectin binding protein, SfbA, that contributes to invasion of brain endothelium and development of meningitis

R Mu, BJ Kim, C Paco, Y Del Rosario… - Infection and …, 2014 - Am Soc Microbiol
ABSTRACT Group B Streptococcus (GBS) is currently the leading cause of neonatal
meningitis. This is due to its ability to survive and multiply in the bloodstream and interact …

Progress toward a group B streptococcal vaccine

JY Song, JH Lim, S Lim, Z Yong… - Human vaccines & …, 2018 - Taylor & Francis
Streptococcus agalactiae (group B Streptococcus, GBS) is a leading cause of severe
invasive disease in neonate, elderly, and immunocompromised patients worldwide. Despite …

Pilus biogenesis of Gram‐positive bacteria: Roles of sortases and implications for assembly

B Khare, S VL Narayana - Protein Science, 2017 - Wiley Online Library
Successful adherence, colonization, and survival of Gram‐positive bacteria require surface
proteins, and multiprotein assemblies called pili. These surface appendages are attractive …

Exploiting pilus-mediated bacteria-host interactions for health benefits

V Sharma, I von Ossowski, V Krishnan - Molecular Aspects of Medicine, 2021 - Elsevier
Surface pili (or fimbriae) are an important but conspicuous adaptation of several genera and
species of Gram-negative and Gram-positive bacteria. These long and non-flagellar multi …

Clostridium perfringens produces an adhesive pilus required for the pathogenesis of necrotic enteritis in poultry

D Lepp, Y Zhou, S Ojha… - Journal of …, 2021 - Am Soc Microbiol
Clostridium perfringens type G strains cause necrotic enteritis (NE) in poultry, an
economically important disease that is a major target of in-feed antibiotics. NE is a …

RTX adhesins are key bacterial surface megaproteins in the formation of biofilms

S Guo, TDR Vance, CA Stevens, I Voets… - Trends in microbiology, 2019 - cell.com
Gram-negative bacteria produce repeats-in-toxin adhesion proteins (RTX adhesins) to
facilitate microbial adhesion. These large, multidomain proteins share a common …

Porphyromonas gingivalis fimbrial protein Mfa5 contains a von Willebrand factor domain and an intramolecular isopeptide

TV Heidler, K Ernits, A Ziolkowska, R Claesson… - Communications …, 2021 - nature.com
Abstract The Gram-negative bacterium Porphyromonas gingivalis is a secondary colonizer
of the oral biofilm and is involved in the onset and progression of periodontitis. Its fimbriae, of …