Signaling by the phosphoinositide 3-kinase family in immune cells
K Okkenhaug - Annual review of immunology, 2013 - annualreviews.org
Phosphoinositide 3-kinases (PI3Ks) control many important aspects of immune cell
development, differentiation, and function. Mammals have eight PI3K catalytic subunits that …
development, differentiation, and function. Mammals have eight PI3K catalytic subunits that …
The regulation of cell motility and chemotaxis by phospholipid signaling
V Kolsch, PG Charest, RA Firtel - Journal of cell science, 2008 - journals.biologists.com
Phosphoinositide 3-kinase (PI3K), PTEN and localized phosphatidylinositol (3, 4, 5)-
trisphosphate [PtdIns (3, 4, 5) P 3] play key roles in chemotaxis, regulating cell motility by …
trisphosphate [PtdIns (3, 4, 5) P 3] play key roles in chemotaxis, regulating cell motility by …
Receptor tyrosine kinases and TLR/IL1Rs unexpectedly activate myeloid cell PI3kγ, a single convergent point promoting tumor inflammation and progression
MC Schmid, CJ Avraamides, HC Dippold, I Franco… - Cancer cell, 2011 - cell.com
Tumor inflammation promotes angiogenesis, immunosuppression, and tumor growth, but the
mechanisms controlling inflammatory cell recruitment to tumors are not well understood. We …
mechanisms controlling inflammatory cell recruitment to tumors are not well understood. We …
Phosphoinositide 3‐kinases in cell migration
RJ Cain, AJ Ridley - Biology of the Cell, 2009 - Wiley Online Library
Cell migration is essential for many biological processes in animals and is a complex highly
co‐ordinated process that involves cell polarization, actin‐driven protrusion and formation …
co‐ordinated process that involves cell polarization, actin‐driven protrusion and formation …
Molecular determinants of PI3Kγ-mediated activation downstream of G-protein–coupled receptors (GPCRs)
Phosphoinositide 3-kinase gamma (PI3Kγ) has profound roles downstream of G-protein–
coupled receptors in inflammation, cardiac function, and tumor progression. To gain insight …
coupled receptors in inflammation, cardiac function, and tumor progression. To gain insight …
Inhibition of PI3K signaling spurs new therapeutic opportunities in inflammatory/autoimmune diseases and hematological malignancies
The phosphoinositide 3-kinase/mammalian target of rapamycin/protein kinase B
(PI3K/mTOR/Akt) signaling pathway is central to a plethora of cellular mechanisms in a wide …
(PI3K/mTOR/Akt) signaling pathway is central to a plethora of cellular mechanisms in a wide …
[HTML][HTML] Directional sensing during chemotaxis
C Janetopoulos, RA Firtel - FEBS letters, 2008 - Elsevier
Cells have the innate ability to sense and move towards a variety of chemoattractants. We
investigate the pathways by which cells sense and respond to chemoattractant gradients …
investigate the pathways by which cells sense and respond to chemoattractant gradients …
PI3K inhibition in inflammation: toward tailored therapies for specific diseases
A Ghigo, F Damilano, L Braccini, E Hirsch - Bioessays, 2010 - Wiley Online Library
In the past decade, the availability of genetically modified animals has enabled the
discovery of interesting roles for phosphatidylinositol 3‐kinase‐γ (PI3Kγ) and‐δ (PI3Kδ) in …
discovery of interesting roles for phosphatidylinositol 3‐kinase‐γ (PI3Kγ) and‐δ (PI3Kδ) in …
Inhibitory role of sphingosine 1-phosphate receptor 2 in macrophage recruitment during inflammation
J Michaud, DS Im, T Hla - The journal of immunology, 2010 - journals.aai.org
Macrophage recruitment to sites of inflammation is an essential step in host defense.
However, the mechanisms preventing excessive accumulation of macrophages remain …
However, the mechanisms preventing excessive accumulation of macrophages remain …