BDNF: a key factor with multipotent impact on brain signaling and synaptic plasticity

P Kowiański, G Lietzau, E Czuba, M Waśkow… - Cellular and molecular …, 2018 - Springer
Brain-derived neurotrophic factor (BDNF) is one of the most widely distributed and
extensively studied neurotrophins in the mammalian brain. Among its prominent functions …

Therapeutic potential of neurotrophins for repair after brain injury: a helping hand from biomaterials

J Houlton, N Abumaria, SFR Hinkley… - Frontiers in …, 2019 - frontiersin.org
Stroke remains the leading cause of long-term disability with limited options available to aid
in recovery. Significant effort has been made to try and minimize neuronal damage following …

Sequential treatment of SH‐SY5Y cells with retinoic acid and brain‐derived neurotrophic factor gives rise to fully differentiated, neurotrophic factor‐dependent, human …

M Encinas, M Iglesias, Y Liu, H Wang… - Journal of …, 2000 - Wiley Online Library
A rapid and simple procedure is presented to obtain nearly pure populations of human
neuron‐like cells from the SH‐SY5Y neuroblastoma cell line. Sequential exposure of SH …

Characterization of differentiated SH-SY5Y as neuronal screening model reveals increased oxidative vulnerability

JI Forster, S Köglsberger, C Trefois… - Journal of …, 2016 - journals.sagepub.com
The immortalized and proliferative cell line SH-SY5Y is one of the most commonly used cell
lines in neuroscience and neuroblastoma research. However, undifferentiated SH-SY5Y …

ω-3 DPA protected neurons from neuroinflammation by balancing microglia M1/M2 polarizations through inhibiting NF-κB/MAPK p38 signaling and activating neuron …

B Liu, Y Zhang, Z Yang, M Liu, C Zhang, Y Zhao… - Marine drugs, 2021 - mdpi.com
Microglia M1 phenotype causes HPA axis hyperactivity, neurotransmitter dysfunction, and
production of proinflammatory mediators and oxidants, which may contribute to the etiology …

BDNF signaling and survival of striatal neurons

M Baydyuk, B Xu - Frontiers in cellular neuroscience, 2014 - frontiersin.org
The striatum, a major component of the basal ganglia, performs multiple functions including
control of movement, reward, and addiction. Dysfunction and death of striatal neurons are …

Altered expression and uptake activity of spinal glutamate transporters after nerve injury contribute to the pathogenesis of neuropathic pain in rats

B Sung, G Lim, J Mao - Journal of Neuroscience, 2003 - Soc Neuroscience
The central glutamatergic system has been implicated in the pathogenesis of neuropathic
pain, and a highly active central glutamate transporter (GT) system regulates the uptake of …

BDNF protects the neonatal brain from hypoxic-ischemic injuryin vivo via the ERK pathway

BH Han, DM Holtzman - Journal of Neuroscience, 2000 - Soc Neuroscience
Neurotrophins activate several different intracellular signaling pathways that in some way
exert neuroprotective effects. In vitro studies of sympathetic and cerebellar granule neurons …

Enhancement of neurite outgrowth in neuronal-like cells following boron nitride nanotube-mediated stimulation

G Ciofani, S Danti, D D'Alessandro, L Ricotti… - ACS …, 2010 - ACS Publications
In this paper, we propose an absolutely innovative technique for the electrical stimulation of
cells, based on piezoelectric nanoparticles. Ultrasounds are used to impart mechanical …

Peripheral brain-derived neurotrophic factor (BDNF) in insomnia: A systematic review and meta-analysis

A Ballesio, A Zagaria, DG Curti, R Moran… - Sleep medicine …, 2023 - Elsevier
The brain-derived neurotrophic factor (BDNF) is associated with emotional and cognitive
functioning, and it is considered a transdiagnostic biomarker for mental disorders. Literature …