Targeting the alternative bile acid synthetic pathway for metabolic diseases

W Jia, M Wei, C Rajani, X Zheng - Protein & cell, 2021 - academic.oup.com
The gut microbiota is profoundly involved in glucose and lipid metabolism, in part by
regulating bile acid (BA) metabolism and affecting multiple BA-receptor signaling pathways …

Bile acids in glucose metabolism and insulin signalling—mechanisms and research needs

TR Ahmad, RA Haeusler - Nature Reviews Endocrinology, 2019 - nature.com
Of all the novel glucoregulatory molecules discovered in the past 20 years, bile acids (BAs)
are notable for the fact that they were hiding in plain sight. BAs were well known for their …

Pregnancy and liver disease

RH Westbrook, G Dusheiko… - Journal of …, 2016 - journal-of-hepatology.eu
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The pathophysiology of intrahepatic cholestasis of pregnancy

PH Dixon, C Williamson - Clinics and Research in Hepatology and …, 2016 - Elsevier
A number of liver disorders are specific to pregnancy. Amongst these, intrahepatic
cholestasis of pregnancy (ICP), also known as obstetric cholestasis (OC), is the commonest …

[HTML][HTML] Fetal cardiac dysfunction in intrahepatic cholestasis of pregnancy is associated with elevated serum bile acid concentrations

T Vasavan, S Deepak, IA Jayawardane, M Lucchini… - Journal of …, 2021 - Elsevier
Background & Aims Intrahepatic cholestasis of pregnancy (ICP) is associated with an
increased risk of stillbirth. This study aimed to assess the relationship between bile acid …

[PDF][PDF] Prognostic and mechanistic potential of progesterone sulfates in intrahepatic cholestasis of pregnancy and pruritus gravidarum

S Abu‐Hayyeh, C Ovadia, TM Lieu, DD Jensen… - …, 2016 - Wiley Online Library
A challenge in obstetrics is to distinguish pathological symptoms from those associated with
normal changes of pregnancy, typified by the need to differentiate whether gestational …

Evaluating the effectiveness and safety of ursodeoxycholic acid in treatment of intrahepatic cholestasis of pregnancy: A meta-analysis (a prisma-compliant study)

X Kong, Y Kong, F Zhang, T Wang, J Yan - Medicine, 2016 - journals.lww.com
Background: Intrahepatic cholestasis of pregnancy (ICP) is a specific pregnancy-related
disorder without standard medical therapies. Ursodeoxycholic acid (UDCA) is the most used …

[HTML][HTML] Heart and bile acids–clinical consequences of altered bile acid metabolism

T Vasavan, E Ferraro, E Ibrahim, P Dixon… - … et Biophysica Acta (BBA …, 2018 - Elsevier
Cardiac dysfunction has an increased prevalence in diseases complicated by liver cirrhosis
such as primary biliary cholangitis and primary sclerosing cholangitis. This observation has …

Intrahepatic cholestasis of pregnancy: Recent advances

C Ovadia, C Williamson - Clinics in Dermatology, 2016 - Elsevier
Intrahepatic cholestasis of pregnancy, also known as obstetric cholestasis, is a pruritic
condition of pregnancy characterized by an underlying elevation in circulating bile acids and …

Perinatal death by bile acid levels in intrahepatic cholestasis of pregnancy: a systematic review

D Di Mascio, J Quist-Nelson, M Riegel… - The Journal of …, 2021 - Taylor & Francis
Background Intrahepatic cholestasis of pregnancy (ICP) is characterized by the elevation of
total bile acids (TBAs). The primary concern in women with ICP is the increased risk of …