Mesenchymal stem/stromal cells as a valuable source for the treatment of immune-mediated disorders

A Markov, L Thangavelu, S Aravindhan… - Stem cell research & …, 2021 - Springer
Over recent years, mesenchymal stem/stromal cells (MSCs) and their potential biomedical
applications have received much attention from the global scientific community in an …

The use of RNA-based treatments in the field of cancer immunotherapy

M Chehelgerdi, M Chehelgerdi - Molecular Cancer, 2023 - Springer
Over the past several decades, mRNA vaccines have evolved from a theoretical concept to a
clinical reality. These vaccines offer several advantages over traditional vaccine techniques …

Exosome-shuttled miR-216a-5p from hypoxic preconditioned mesenchymal stem cells repair traumatic spinal cord injury by shifting microglial M1/M2 polarization

W Liu, Y Rong, J Wang, Z Zhou, X Ge, C Ji… - Journal of …, 2020 - Springer
Background Spinal cord injury (SCI) can lead to severe motor and sensory dysfunction with
high disability and mortality. In recent years, mesenchymal stem cell (MSC)-secreted nano …

Cancer stem cells (CSCs) in drug resistance and their therapeutic implications in cancer treatment

LTH Phi, IN Sari, YG Yang, SH Lee, N Jun… - Stem cells …, 2018 - Wiley Online Library
Cancer stem cells (CSCs), also known as tumor‐initiating cells (TICs), are suggested to be
responsible for drug resistance and cancer relapse due in part to their ability to self‐renew …

Neural stem cell-derived small extracellular vesicles attenuate apoptosis and neuroinflammation after traumatic spinal cord injury by activating autophagy

Y Rong, W Liu, J Wang, J Fan, Y Luo, L Li, F Kong… - Cell death & …, 2019 - nature.com
Spinal cord injury (SCI) can cause severe irreversible motor dysfunction and even death.
Neural stem cell (NSC) transplantation can promote functional recovery after acute SCI in …

Mesenchymal stromal cell therapeutic delivery: translational challenges to clinical application

H Caplan, SD Olson, A Kumar, M George… - Frontiers in …, 2019 - frontiersin.org
For several decades, multipotent mesenchymal stromal cells (MSCs) have been extensively
studied for their therapeutic potential across a wide range of diseases. In the preclinical …

Exosomes derived from bone mesenchymal stem cells repair traumatic spinal cord injury by suppressing the activation of A1 neurotoxic reactive astrocytes

W Liu, Y Wang, F Gong, Y Rong, Y Luo… - Journal of …, 2019 - liebertpub.com
Mesenchymal stem cell (MSC) transplantation is now considered as an effective treatment
strategy for traumatic spinal cord injury (SCI). However, several key issues remain …

Mesenchymal stem cell therapy in the treatment of osteoarthritis: reparative pathways, safety and efficacy–a review

J Freitag, D Bates, R Boyd, K Shah, A Barnard… - BMC musculoskeletal …, 2016 - Springer
Osteoarthritis is a leading cause of pain and disability across the world. With an aging
population its prevalence is likely to further increase. Current accepted medical treatment …

Mesenchymal Stem Cells Derived from Dental Tissues vs. Those from Other Sources: Their Biology and Role in Regenerative Medicine

GTJ Huang, S Gronthos, S Shi - Journal of dental research, 2009 - journals.sagepub.com
To date, 5 different human dental stem/progenitor cells have been isolated and
characterized: dental pulp stem cells (DPSCs), stem cells from exfoliated deciduous teeth …

Concise review: adipose‐derived stem cells as a novel tool for future regenerative medicine

H Mizuno, M Tobita, AC Uysal - Stem cells, 2012 - academic.oup.com
The potential use of stem cell‐based therapies for the repair and regeneration of various
tissues and organs offers a paradigm shift that may provide alternative therapeutic solutions …