How to completely squeeze a fungus—advanced genome mining tools for novel bioactive substances

A Schüller, L Studt-Reinhold, J Strauss - Pharmaceutics, 2022 - mdpi.com
Fungal species have the capability of producing an overwhelming diversity of bioactive
substances that can have beneficial but also detrimental effects on human health. These so …

H3K27me3 is vital for fungal development and secondary metabolite gene silencing, and substitutes for the loss of H3K9me3 in the plant pathogen Fusarium …

L Studt-Reinhold, AK Atanasoff-Kardjalieff… - PLoS …, 2024 - journals.plos.org
Facultative heterochromatin marked by histone H3 lysine 27 trimethylation (H3K27me3) is
an important regulatory layer involved in secondary metabolite (SM) gene silencing and …

[HTML][HTML] Detection and quantification of the histone code in the fungal genus Aspergillus

X Zhang, R Noberini, A Vai, T Bonaldi, MF Seidl… - Fungal Genetics and …, 2023 - Elsevier
In eukaryotes, the combination of different histone post-translational modifications (PTMs)–
the histone code–impacts the chromatin organization as compact and transcriptionally silent …

Genomic Localization Bias of Secondary Metabolite Gene Clusters and Association with Histone Modifications in Aspergillus

X Zhang, I Leahy, J Collemare… - Genome Biology and …, 2024 - academic.oup.com
Fungi are well-known producers of bioactive secondary metabolites (SMs), which have been
exploited for decades by humankind for various medical applications like therapeutics and …

Genomic localization bias of secondary metabolite gene clusters and association with histone modifications in Aspergillus

X Zhang, I Leahy, J Collemare, MF Seidl - bioRxiv, 2024 - biorxiv.org
Fungi are well-known producers of bioactive secondary metabolites (SMs), which have been
exploited for decades by humankind for various medical applications like therapeutics and …

[PDF][PDF] The Epigenetic Approaches in Filamentous Fungi

E Özsoy, Ö Sefer, E Yörük - Biotechnological Advances for …, 2022 - researchgate.net
Epigenetics mean that mechanisms showing their effects through gene expression without
changes in the DNA sequence. Though the inheritance of epigenetics mechanisms is not …