Impact of diabetes in patients diagnosed with COVID-19

M Abu-Farha, F Al-Mulla, TA Thanaraj… - Frontiers in …, 2020 - frontiersin.org
COVID-19 is a disease caused by the coronavirus SARS-CoV-2 (Severe Acute Respiratory
Syndrome Coronavirus-2), known as a highly contagious disease, currently affecting more …

The two faces of ACE2: the role of ACE2 receptor and its polymorphisms in hypertension and COVID-19

M Bosso, TA Thanaraj, M Abu-Farha… - … Therapy Methods & …, 2020 - cell.com
The mechanism for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
infection requires the binding of the virus to the angiotensin-converting enzyme 2 (ACE2) …

ACE2, TMPRSS2, and Furin variants and SARS‐CoV‐2 infection in Madrid, Spain

L Torre‐Fuentes, J Matías‐Guiu… - Journal of medical …, 2021 - Wiley Online Library
It has been suggested that some individuals may present genetic susceptibility to SARS‐
CoV‐2 infection, with particular research interest in variants of the ACE2 and TMPRSS2 …

Clinical characteristics of coronavirus disease 2019 (COVID-19) patients in Kuwait

A Alshukry, H Ali, Y Ali, T Al-Taweel, M Abu-Farha… - PloS one, 2020 - journals.plos.org
This is a retrospective single-center study of 417 consecutive patients with coronavirus
disease 2019 (COVID-19) admitted to Jaber Al-Ahmad Hospital in Kuwait between February …

Pharmacogenomics and COVID-19: clinical implications of human genome interactions with repurposed drugs

OA Badary - The pharmacogenomics journal, 2021 - nature.com
The outbreak of Coronavirus disease 2019 (COVID-19) has evolved into an emergent global
pandemic. Many drugs without established efficacy are being used to treat COVID-19 …

ACE2 Nascence, trafficking, and SARS-CoV-2 pathogenesis: the saga continues

S Badawi, BR Ali - Human genomics, 2021 - Springer
With the emergence of the novel coronavirus SARS-CoV-2 since December 2019, more
than 65 million cases have been reported worldwide. This virus has shown high infectivity …

Remdesivir MD simulations suggest a more favourable binding to SARS-CoV-2 RNA dependent RNA polymerase mutant P323L than wild-type

A Mohammad, F Al-Mulla, DQ Wei, J Abubaker - Biomolecules, 2021 - mdpi.com
SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) protein is the target for the antiviral
drug Remdesivir (RDV). With RDV clinical trials on COVID-19 patients showing a reduced …

The double edge sword of testosterone's role in the COVID-19 pandemic

JS Younis, K Skorecki, Z Abassi - Frontiers in Endocrinology, 2021 - frontiersin.org
COVID-19 is a complex disease with a multifaceted set of disturbances involving several
mechanisms of health and disease in the human body. Sex hormones, estrogen, and …

Outcomes of COVID-19: Disparities by ethnicity

H Ali, A Alshukry, SK Marafie, M AlRukhayes… - Infection, Genetics and …, 2021 - Elsevier
Objectives To investigate the role of ethnicity in COVID-19 outcome disparities in a cohort in
Kuwait. Methods This is a retrospective analysis of 405 individuals infected with SARS-CoV …

Human genetic basis of severe or critical illness in COVID-19

XS Ji, B Chen, B Ze, WH Zhou - Frontiers in cellular and infection …, 2022 - frontiersin.org
Coronavirus Disease 2019 (COVID-19) caused by the novel severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) has led to considerable morbidity and mortality …