Because understanding amyloid fibrillation in molecular detail is essential for development
of strategies to control amyloid formation and overcome neurodegenerative disorders …

Congo red is a commonly used histological dye for amyloid detection. The specificity of this
staining results from Congo red's affinity for binding to fibril proteins enriched in β-sheet …

Congo red (CR) binding, monitored by characteristic yellow-green birefringence under
crossed polarization has been used as a diagnostic test for the presence of amyloid in tissue …

Prion diseases are transmissible, invariably fatal, neurodegenerative diseases which
include Creutzfeldt–Jakob disease (CJD) in humans and bovine spongiform …

Aggregation of proteins and peptides is a widespread and much-studied problem, with
serious implications in contexts ranging from biotechnology to human disease. An …

Based on in vitro observations in scrapie-infected neuroblastoma cells, quinacrine has
recently been proposed as a treatment for Creutzfeldt-Jakob disease (CJD), including a new …

Recent progress determining the structure of the host-encoded prion protein (PrPC) and the
role of auxiliary molecules in prion replication permits a more rational approach in the …

In order to study the effect of oxidation on the dye-binding behavior of myofibrillar proteins,
selected dyes with different charges (positively charged Sarfarin O (SO), neutral …

Our discovery of dominant-negative inhibition of prion formation in cultured cells provided an
explanation for the resistance of some sheep to scrapie and humans to Creutzfeldt–Jakob …

Inhibition of the accumulation of protease-resistant prion protein (PrP-res) is a prime strategy
in the development of potential transmissible spongiform encephalopathy (TSE) …