The intercalated disc (ID) is a highly specialized structure that connects cardiomyocytes via
mechanical and electrical junctions. Although described in some detail by light microscopy …

Youth and adult participation in sports continues to increase, and athletes may be
diagnosed with potentially arrhythmogenic cardiac conditions. This international …

Aims Arrhythmogenic cardiomyopathy (ACM) is characterized by progressive loss of
cardiomyocytes, and fibrofatty tissue replacement. Extracellular vesicles (EVs) secreted by …

Recent evidence shows a close link between Parkinson's disease (PD) and cardiac
dysfunction with limited treatment options. Mitophagy plays a crucial role in the control of …

Background: Exercise training, and catecholaminergic stimulation, increase the incidence of
arrhythmic events in patients affected with arrhythmogenic right ventricular cardiomyopathy …

Dilated cardiomyopathy (DCM) is a leading cause of heart failure and the most common
indication for heart transplantation. Currently, there is still an unmet clinical need in effective …

Background: Abnormalities in cardiac energy metabolism occur in heart failure (HF) and
contribute to contractile dysfunction, but their role, if any, in HF-related pathologic …

Apoptosis-inducing factor (AIF) is a mitochondrial intermembrane space flavoprotein with
diverse functions in cellular physiology. In this regard, a large number of studies have …

Background: Arrhythmogenic right ventricular cardiomyopathy (ARVC) is characterized by
high propensity to life-threatening arrhythmias and progressive loss of heart muscle. More …

Cardiovascular diseases (CVDs) are leading causes of global mortality; however, their
underlying mechanisms remain unclear. The tumor suppressor factor p53 has been …