[HTML][HTML] Histidine tautomerism dependent conformational transitions driven aggregation of profilin-1: Implications in amyotrophic lateral sclerosis
G Muneeswaran, JY Lee - International Journal of Biological …, 2022 - Elsevier
Abstract Aggregation of profilin-1 (PFN1) causes a fatal neurodegenerative disease, familial
amyotrophic lateral sclerosis (fALS). Histidine (His) tautomerism has been linked to the …
amyotrophic lateral sclerosis (fALS). Histidine (His) tautomerism has been linked to the …
Monitoring early-stage β-amyloid dimer aggregation by histidine site-specific two-dimensional infrared spectroscopy in a simulation study
Monitoring early-stage β-amyloid (Aβ) dimerization is a formidable challenge for
understanding neurological diseases. We compared β-sheet formation and histidine site …
understanding neurological diseases. We compared β-sheet formation and histidine site …
Exposure to the electric field: A potential way to block the aggregation of histidine tautomeric isomers of β-amyloid
A Salimi, S Chatterjee, JY Lee - International Journal of Biological …, 2023 - Elsevier
Controlling protein misfolding and accumulation in neurodegeneration is a challenge in
chemical neuroscience. The application of appropriate electric fields (EFs) can be a …
chemical neuroscience. The application of appropriate electric fields (EFs) can be a …