Natural-product-based fluorescent probes: recent advances and applications

DB Sung, JS Lee - RSC Medicinal Chemistry, 2023 - pubs.rsc.org
Fluorescent probes are attractive tools for biology, drug discovery, disease diagnosis, and
environmental analysis. In bioimaging, these easy-to-operate and inexpensive probes can …

Triterpenoids as reactive oxygen species modulators of cell fate

T Ling, L Boyd, F Rivas - Chemical Research in Toxicology, 2022 - ACS Publications
The triterpenoid natural products have played an important role in understanding
mechanistic models of human diseases. These natural products are diverse, but many have …

Structure and biological activity of ergostane-type steroids from fungi

VN Zhabinskii, P Drasar, VA Khripach - Molecules, 2022 - mdpi.com
Mushrooms are known not only for their taste but also for beneficial effects on health
attributed to plethora of constituents. All mushrooms belong to the kingdom of fungi, which …

Early preclinical studies of ergosterol peroxide and biological evaluation of its derivatives

T Ling, LV Arroyo-Cruz, WR Smither, EK Seighman… - ACS …, 2024 - ACS Publications
Ganoderma lucidum is a medicinal mushroom that produces various pharmacological
compounds, including triterpenoids. A major bioactive component of G. lucidum is ergosterol …

[HTML][HTML] Mitochondrial targeted modification and anticancer mechanism of natural product ergosterol peroxide

P Liu, Y Yang, Z Zhou, X Zhang, X Liu, J Li - Bioorganic Chemistry, 2024 - Elsevier
Ergosterol peroxide (EP) isolated from the edible medicinal fungus Pleurotus ferulae has a
wide range of anti-tumor activity, but poor water solubility and low bioavailability limit further …

Natural Peroxides from Plants: Historical Discovery, Biosynthesis, and Biological Activities

MA Asmaey, A Hamed, M Shaaban - Chemistry & Biodiversity, 2024 - Wiley Online Library
Naturally occurring peroxides received great interest and attention from scientific research
groups worldwide due to their structural diversity, versatile biological activities, and …

Isolation and characterization of ergosterol from Monascus anka for anti-lipid peroxidation properties

Z Yongxia, X Jian, H Suyuan, N Aixin… - Journal de mycologie …, 2020 - Elsevier
Unbalanced lipid peroxidation damages the human body, and is associated with the
formation of tumors, infections, inflammations, autoimmune diseases, and cardiovascular …

Synthesis of ergosterol peroxide conjugates as mitochondria targeting probes for enhanced anticancer activity

M Bu, H Li, H Wang, J Wang, Y Lin, Y Ma - Molecules, 2019 - mdpi.com
Inspired by the significant bioactivity of ergosterol peroxide, we designed and synthesized
four fluorescent coumarin and ergosterol peroxide conjugates 8a–d through the combination …

Plant-derived endoperoxides: structure, occurrence, and bioactivity

JF Tamez-Fernández, EM Melchor-Martínez… - Phytochemistry …, 2020 - Springer
Endoperoxides have received widespread interest as a research topic due to its ubiquitous
structure, which confers interesting biological properties. It has been demonstrated that …

Bioinspired Two-Phase Synthesis of Gibbosterol A

Y Ning, Y Wang, J Gui - JACS Au, 2024 - ACS Publications
The disecosteroid natural product gibbosterol A─ which has a 14/5-bicyclic framework, a
high oxidation state, and a twisted trans-9, 11-epoxy motif─ is the first water-soluble 5, 10: 8 …