ApoE on high-density lipoproteins is primarily responsible for lipid transport and cholesterol
homeostasis in the central nervous system (CNS). Normally produced mostly by astrocytes …

Reactive Oxygen Species (ROS) are produced during normal cellular function. ROS include
hydroxyl radicals, superoxide anion, hydrogen peroxide and nitric oxide. They are very …

Abstract Aims/Introduction The aim of the present study was to investigate the association
between diabetes and the risk of all type dementia (ATD), A lzheimer's disease (AD) and …

The molecular mechanisms controlling synaptogenesis in the central nervous system (CNS)
are poorly understood. Previous reports showed that a glia-derived factor strongly promotes …

Type 2 diabetes may be a risk factor for dementia, but the associated pathological
mechanisms remains unclear. We evaluated the association of diabetes alone or combined …

The central nervous system accounts for only 2% of the whole body mass but contains
almost a quarter of the unesterified cholesterol present in the whole individual. This sterol is …

Cholesterol is a multifacetted molecule. First, it serves as an essential membrane
component, as a cofactor for signaling molecules and as a precursor for steroid hormones; …

Inflammatory reaction is thought to be an important contributor to neuronal damage in
neurodegenerative disorders such as Alzheimer's disease (AD), Parkinson's disease (PD) …

Cholesterol is a multifaceted molecule, which serves as essential membrane component, as
cofactor for signaling molecules and as precursor for steroid hormones. Consequently …

Brain function depends on the cooperation between highly specialized cells. Neurons
generate electrical signals and glial cells provide structural and metabolic support. Here, I …