Background: Chronic postsurgical pain can severely impair patient health and quality of life.
This systematic review update evaluated the effectiveness of systemic drugs to prevent …

The development of chronic pain is considered a major complication after surgery. Basic
science research in animal models helps us understand the transition from acute to chronic …

Objective To describe rates and risk factors for prolonged postoperative use of opioids in
patients who had not previously used opioids and undergoing major elective surgery …

Background: Persistent pain after breast cancer surgery affects up to 60% of patients. Early
identification of those at higher risk could help inform optimal management. We conducted a …

The past 20 years have seen an increasing recognition of the burden of chronic pain after
surgery and other trauma. There is now good evidence that chronic postsurgical pain …

Persistent postsurgical pain is a prevalent but underacknowledged condition. The aim of this
study was to assess the prevalence, sensory qualities, and postoperative determinants of …

Severe persistent post-surgical pain (PPP) affects 2–10% of adults undergoing surgery, 1
corresponding to at least 140 000 patients per year presenting with disabling pain in the UK …

In the past ten years there has been recognition that chronic post-surgical pain is a
significant problem. This is a complex area of research and although the quality of studies …

Most patients who undergo surgery recover uneventfully and resume their normal daily
activities within weeks. Nevertheless, chronic postsurgical pain develops in an alarming …

BACKGROUND: Many clinical trials have demonstrated the effectiveness of gabapentin and
pregabalin administration in the perioperative period as an adjunct to reduce acute …