In image-based profiling, software extracts thousands of morphological features of cells from
multi-channel fluorescence microscopy images, yielding single-cell profiles that can be used …

Scalable sequence–function studies have enabled the systematic analysis and cataloging of
hundreds of thousands of coding and noncoding genetic variants in the human genome …

White adipose tissue, once regarded as morphologically and functionally bland, is now
recognized to be dynamic, plastic and heterogenous, and is involved in a wide array of …

For any given level of overall adiposity, individuals vary considerably in fat distribution. The
inherited basis of fat distribution in the general population is not fully understood. Here, we …

Obesity-associated morbidity is exacerbated by abdominal obesity, which can be measured
as the waist-to-hip ratio adjusted for the body mass index (WHRadjBMI). Here we identify …

Modern quantitative image analysis techniques have enabled high-throughput, high-content
imaging experiments. Image-based profiling leverages the rich information in images to …

Aims/hypothesis Type 2 diabetes is highly polygenic and influenced by multiple biological
pathways. Rapid expansion in the number of type 2 diabetes loci can be leveraged to …

Phenotypic profiling by high throughput microscopy, including Cell Painting, has become a
leading tool for screening large sets of perturbations in cellular models. To efficiently …

Recent large-scale genomic association studies found evidence for a genetic link between
increased risk of type 2 diabetes and decreased risk for adiposity-related traits, reminiscent …

Obesity strongly increases the risk of cardiometabolic diseases, yet the underlying mediators
of this relationship are not fully understood. Given that obesity strongly influences circulating …