Cancer-associated fibroblasts: Origin, function, imaging, and therapeutic targeting
The tumor microenvironment (TME) is emerging as one of the primary barriers in cancer
therapy. Cancer-associated fibroblasts (CAF) are a common inhabitant of the TME in several …
therapy. Cancer-associated fibroblasts (CAF) are a common inhabitant of the TME in several …
Targeted therapy for head and neck cancer: signaling pathways and clinical studies
Head and neck cancer (HNC) is malignant, genetically complex and difficult to treat and is
the sixth most frequent cancer, with tobacco, alcohol and human papillomavirus being major …
the sixth most frequent cancer, with tobacco, alcohol and human papillomavirus being major …
Microenvironment-driven intratumoral heterogeneity in head and neck cancers: clinical challenges and opportunities for precision medicine
H Zaryouh, M Vara-Messler, J Vignau… - Drug Resistance …, 2022 - Elsevier
Squamous cell carcinoma of the head and neck (SCCHN) is among the most prevalent
cancer types worldwide. Despite multimodal therapeutic approaches that include surgical …
cancer types worldwide. Despite multimodal therapeutic approaches that include surgical …
[HTML][HTML] The tumor microenvironment contribution to development, growth, invasion and metastasis of head and neck squamous cell carcinomas
S Koontongkaew - Journal of Cancer, 2013 - ncbi.nlm.nih.gov
Head and neck squamous cell carcinoma (HNSCC) is a complex tissue that contains tumor
cells and the surrounding stroma, which is populated by different types of mesenchymal …
cells and the surrounding stroma, which is populated by different types of mesenchymal …
Emerging biomarkers in head and neck cancer in the era of genomics
Head and neck cancer (HNC) broadly includes carcinomas arising from the mucosal
epithelia of the head and neck region as well as various cell types of salivary glands and the …
epithelia of the head and neck region as well as various cell types of salivary glands and the …
[HTML][HTML] Targeting tumor microenvironment by small-molecule inhibitors
S Zhong, JH Jeong, Z Chen, Z Chen, JL Luo - Translational oncology, 2020 - Elsevier
The tumor microenvironment (TME) is a hypoxic, acidic, and immune/inflammatory cell–
enriched milieu that plays crucial roles in tumor development, growth, progression, and …
enriched milieu that plays crucial roles in tumor development, growth, progression, and …
Cancer-associated fibroblasts drive glycolysis in a targetable signaling loop implicated in head and neck squamous cell carcinoma progression
Despite aggressive therapies, head and neck squamous cell carcinoma (HNSCC) is
associated with a less than 50% 5-year survival rate. Late-stage HNSCC frequently consists …
associated with a less than 50% 5-year survival rate. Late-stage HNSCC frequently consists …
Dual relationship between stromal cells and immune cells in the tumor microenvironment
The tumor microenvironment (TME) plays a critical role in tumorigenesis and is comprised of
different components, including tumor cells, stromal cells, and immune cells. Among them …
different components, including tumor cells, stromal cells, and immune cells. Among them …
Transforming growth factor‑β signaling in head and neck squamous cell carcinoma: Insights into cellular responses
X Pang, YL Tang, XH Liang - Oncology letters, 2018 - spandidos-publications.com
Head and neck squamous cell carcinoma (HNSCC) arises in the oral cavity, salivary glands,
larynx, pharynx, nasal cavity and paranasal sinuses, and is characterized by high morbidity …
larynx, pharynx, nasal cavity and paranasal sinuses, and is characterized by high morbidity …
Fibroblast growth factor (FGF) receptor/FGF inhibitors: novel targets and strategies for optimization of response of solid tumors
C Hierro, J Rodon, J Tabernero - Seminars in oncology, 2015 - Elsevier
The fibroblast growth factor receptor (FGFR) pathway plays a major role in several biological
processes, from organogenesis to metabolism homeostasis and angiogenesis. Several …
processes, from organogenesis to metabolism homeostasis and angiogenesis. Several …