Chemical modification of protein is an arduous but fruitful task. Many chemical methods
have been developed for such purpose by carefully balancing reactivity and selectivity. Now …

The widespread applications of benzophenone (BP) photochemistry in biological chemistry,
bioorganic chemistry, and material science have been prominent in both academic and …

Aptamers comprise a range of molecular recognition scaffolds that can be engineered to
bind to a legion of different proteins and other targets with excellent specificity and affinity …

Small GTPases are a family of low molecular weight GTP-hydrolyzing enzymes that cycle
between an inactive state when bound to GDP and an active state when associated to GTP …

Cu2O as the catalyst in water was found to be quite robust for the azide-alkyne cycloaddition
(AAC) reaction, which was verified by a wide variety of applicable azides and alkynes. Water …

Signaling by ErbB receptors requires the activation of their cytoplasmic kinase domains,
which is initiated by ligand binding to the receptor ectodomains. Cytoplasmic factors …

Abstract ADP-ribosylation factor 6 (Arf6), a small G-protein of the Ras superfamily, plays
pivotal roles in multiple cellular events, including exocytosis, endocytosis, actin remodeling …

A multifunctional reagent based on a coumarin scaffold was developed for derivatization of
naive RNA. The alkylating agent N3BC [7-azido-4-(bromomethyl) coumarin], obtained by …

Almiramide C is a marine natural product with low micromolar activity against Leishmania
donovani, the causative agent of leishmaniasis. We have now shown that almiramide C is …

Virtual screening (VS) of chemical libraries formatted in silico provides an alternative to
experimental high-throughput screening (HTS) for the identification of small molecule …