Publisher Summary This chapter discusses the structure and function of the epidermal
growth factor (EGF) receptor (EGFR), from ligand binding to the initiation of intracellular …

Recent studies have demonstrated that mitogen-activated protein kinases (MAPKs),
including Jun N-terminus kinase (JNK), p38 and Erk, play crucial roles in cell migration. JNK …

Spermatogenesis is the process by which a single spermatogonium develops into 256
spermatozoa, one of which will fertilize the ovum. Since the 1950s when the stages of the …

The receptor for the epidermal growth factor (EGF) and related ligands (EGFR), the
prototypal member of the superfamily of receptors with intrinsic tyrosine kinase activity, is …

Integrin adhesion receptors play a crucial role in regulating interactions between cells and
extracellular matrix (ECM). Integrin activation initiates multiple intracellular signaling …

Mucosal repair is a complex event that immediately follows acute injury induced by ischemia
and noxious luminal contents such as bile. In the small intestine, villous contraction is the …

The anti-tumor role and mechanisms of Cannabidiol (CBD), a non-psychotropic cannabinoid
compound, are not well studied especially in triple-negative breast cancer (TNBC). In the …

Clustering of integrins into focal adhesions and focal complexes is regulated by the actin
cytoskeleton. In turn, actin dynamics are governed by Rho family GTPases. Integrin …

Receptor and cytoplasmic protein tyrosine kinases play prominent roles in the control of a
range of cellular processes during embryonic development and in the regulation of many …

We describe the design, construction, and characterization of microfluidic devices for
studying cell adhesion and cell mechanics. The method offers multiple advantages over …