ETS-related gene (ERG) is a member of the E-26 transformation-specific (ETS) family of
transcription factors with roles in development that include vasculogenesis, angiogenesis …

The Ets-related gene (ERG) is an Ets-transcription factor required for normal blood stem cell
development. ERG expression is down-regulated during early T-lymphopoiesis but …

Overexpression of the ETS transcription factor ERG is an adverse prognostic factor in adult
patients with acute myeloid leukemia (AML) and T-cell acute lymphoblastic leukemia (T …

Aberrant transcriptional programs in combination with abnormal proliferative signaling drive
leukemic transformation. These programs operate in normal hematopoiesis where they are …

The genomics era has facilitated the discovery of new genes that predispose individuals to
bone marrow failure (BMF) and hematological malignancy (HM). We report the discovery of …

Long‐term disease‐free survival in adults with T‐cell acute lymphoblastic leukemia (T‐ALL)
remains poor, particularly after relapse, with few available salvage options. Preclinical data …

MicroRNA-224 is overexpressed in various malignant tumors with poor prognosis, which
plays a critical role in biological processes including cell proliferation, apoptosis and several …

Abstract E-26 Transformation Specific (ETS) transcription factors are known to cause various
cancers and their aberrant expression has been related to various oncogenic processes like …

DNA methylation is a dynamic epigenetic mark that characterizes different cellular
developmental stages, including tissue-specific profiles. This CpG dinucleotide modification …

The T-cell oncogene Lim-only 2 (LMO2) critically influences both normal and malignant
haematopoiesis. LMO2 is not normally expressed in T cells, yet ectopic expression is seen …