Parkinson's disease (PD) is a common neurodegenerative disorder. While a number of
nonmotor manifestations arise, the typical clinical features involve a movement disorder …

A relatively small number of especially susceptible nerve cell types within multiple
neurotransmitter systems of the human central, peripheral, and enteric nervous systems …

Many aspects of cognition and behaviour are regulated by noradrenergic projections to the
forebrain originating from the locus coeruleus, acting through alpha and beta …

Purpose This joint practice guideline or procedure standard was developed collaboratively
by the European Association of Nuclear Medicine (EANM) and the Society of Nuclear …

The recent formalization of clinical criteria for Parkinson's disease with dementia (PDD)
codifies many studies on this topic, including those assessing biological correlates. These …

Ageing leads to a functional deterioration of many brain systems, including the circadian
clock—an internal time-keeping system that generates∼ 24-hour rhythms in physiology and …

Abstract Parkinson's disease (PD), one of the most frequent neurodegenerative disorders, is
no longer considered a complex motor disorder characterized by extrapyramidal symptoms …

The locus coeruleus (LC) contains norepinephrine (NE)-synthesizing neurons that send
diffuse projections throughout the central nervous system. The LC-NE system has a major …

Over the past three decades, neuroimaging studies—including structural, functional and
molecular modalities—have provided invaluable insights into the mechanisms underlying …

Background Findings from longitudinal follow-up studies in patients with idiopathic rapid-eye-
movement sleep behaviour disorder (IRBD) have shown that most patients will eventually …