With the increasing risk of invasive and life threating fungal infections, there is now a great
concern regarding the lower discovery rate of antifungal drugs in comparison to …

Due to the complexity of multifactorial diseases, single-target drugs do not always exhibit
satisfactory efficacy. Recently, increasing evidence indicates that simultaneous modulation …

Abstract The copper (I)‐catalyzed 1, 2, 3‐triazole‐forming reaction between azides and
terminal alkynes has become the gold standard of 'click chemistry'due to its reliability …

During the past years, a variety of scientific and methodological developments have been
achieved, which urge chemists to increase the tools of their arsenal to improve the ease and …

In recent years their has been an increased use of antifungal agents and has resulted in the
development of resistance to drugs. Currently, use of standard antifungal therapies can be …

The Huisgen 1, 3-dipolar cycloaddition reaction of organic azides and alkynes1, 2 has
gained considerable attention in recent years due to the introduction in 2001 of Cu (1) …

Despite enormous progress in the field of the synthetic chemistry involving, for example,
catalytic and combinatorial synthesis of a large libraries of compounds, multicomponent …

Fluconazole based novel mimics containing 1, 2, 3-triazole were designed and synthesized
as antifungal agents. Their antifungal activities were evaluated in vitro by measuring the …

The Hedgehog (Hh) signal is transduced across the membrane by the heptahelical protein
Smoothened (Smo), a developmental regulator, oncoprotein and drug target in oncology …

Synthesis of novel 1, 2, 3-triazole-linked β-lactam–bile acid conjugates 17–24 using 1, 3-
dipolar cycloaddition reaction of azido β-lactam and terminal alkyne of bile acids in the …