Vaginal microbiota and the potential of Lactobacillus derivatives in maintaining vaginal health

WJY Chee, SY Chew, LTL Than - Microbial cell factories, 2020 - Springer
Human vagina is colonised by a diverse array of microorganisms that make up the normal
microbiota and mycobiota. Lactobacillus is the most frequently isolated microorganism from …

Contribution of Lactobacillus iners to Vaginal Health and Diseases: A Systematic Review

N Zheng, R Guo, J Wang, W Zhou… - Frontiers in cellular and …, 2021 - frontiersin.org
Lactobacillus iners, first described in 1999, is a prevalent bacterial species of the vaginal
microbiome. As L. iners does not easily grow on de Man-Rogosa-Sharpe agar, but can grow …

The cervicovaginal mucus barrier

G Lacroix, V Gouyer, F Gottrand… - International Journal of …, 2020 - mdpi.com
Preterm births are a global health priority that affects 15 million babies every year worldwide.
There are no effective prognostic and therapeutic strategies relating to preterm delivery, but …

Cysteine dependence of Lactobacillus iners is a potential therapeutic target for vaginal microbiota modulation

SM Bloom, NA Mafunda, BM Woolston… - Nature …, 2022 - nature.com
Vaginal microbiota composition affects many facets of reproductive health. Lactobacillus
iners-dominated microbial communities are associated with poorer outcomes, including …

Untangling mucosal drug delivery: engineering, designing, and testing nanoparticles to overcome the mucus barrier

J Watchorn, AJ Clasky, G Prakash… - ACS Biomaterials …, 2022 - ACS Publications
Mucus is a complex viscoelastic gel and acts as a barrier covering much of the soft tissue in
the human body. High vascularization and accessibility have motivated drug delivery to …

Bacterial and host determinants of group B streptococcal vaginal colonization and ascending infection in pregnancy

A Brokaw, A Furuta, M Dacanay… - Frontiers in cellular …, 2021 - frontiersin.org
Group B streptococcus (GBS) is a gram-positive bacteria that asymptomatically colonizes the
vaginal tract. However, during pregnancy maternal GBS colonization greatly predisposes …

A review of the diversity of the genital tract microbiome and implications for fertility of cattle

M Adnane, A Chapwanya - Animals, 2022 - mdpi.com
Simple Summary Reproductive systems of cattle contain multiple microbes resident in the
female from a young age. Sometimes other harmful microbes can invade the genital tract …

Insight into the ecology of vaginal bacteria through integrative analyses of metagenomic and metatranscriptomic data

MT France, L Fu, L Rutt, H Yang, MS Humphrys… - Genome Biology, 2022 - Springer
Background Vaginal bacterial communities dominated by Lactobacillus species are
associated with a reduced risk of various adverse health outcomes. However, somewhat …

[HTML][HTML] Vaginal Lactobacillus fatty acid response mechanisms reveal a metabolite-targeted strategy for bacterial vaginosis treatment

M Zhu, MW Frank, CD Radka, S Jeanfavre, J Xu… - Cell, 2024 - cell.com
Bacterial vaginosis (BV), a common syndrome characterized by Lactobacillus-deficient
vaginal microbiota, is associated with adverse health outcomes. BV often recurs after …

Avoiding a sticky situation: bypassing the mucus barrier for improved local drug delivery

HC Zierden, A Josyula, RL Shapiro, HT Hsueh… - Trends in molecular …, 2021 - cell.com
The efficacy of drugs administered by traditional routes is limited by numerous biological
barriers that preclude reaching the intended site of action. Further, full body systemic …