This review provides an overview of the engineering and application of extracellular matrix
(ECM) hydrogels. ECM hydrogels are attractive materials for tissue engineering and …

Chronic lung diseases result from alteration and/or destruction of lung tissue, inevitably
causing decreased breathing capacity and quality of life for patients. While animal models …

Decellularized lung scaffolds and hydrogels are increasingly being utilized in ex vivo lung
bioengineering. However, the lung is a regionally heterogenous organ with proximal and …

Peroxidasin (PXDN) is a secreted heme peroxidase that catalyzes the oxidative crosslinking
of collagen IV within the extracellular matrix (ECM) via intermediate hypobromous acid …

Alveolar type 2 epithelial cells (AT2s) derived from human induced pluripotent stem cells
(iAT2s) have rapidly contributed to our understanding of AT2 function and disease …

Abstract Idiopathic Pulmonary Fibrosis (IPF) is a progressively debilitating lung condition
characterized by oxidative stress, cell phenotype shifts, and excessive extracellular matrix …

The extracellular matrix (ECM) is not just a three-dimensional scaffold that provides stable
support for all cells in the lungs, but also an important component of chronic fibrotic airway …

Extracellular matrix (ECM) remodeling has been implicated in the irreversible obstruction of
airways and destruction of alveolar tissue in chronic obstructive pulmonary disease (COPD) …

Abnormal deposition of extracellular matrix (ECM) in lung tissue is a characteristic of
idiopathic pulmonary fibrosis (IPF). Increased collagen deposition is also accompanied by …

Being a vital organ exposed to the external environment, the lung is susceptible to a
plethora of pathogens and pollutants. This is reflected in high incidences of chronic …