Tumor microenvironment (TME) is a specialized ecosystem of host components, designed
by tumor cells for successful development and metastasis of tumor. With the advent of 3D …

Recent breakthroughs in cancer immunotherapy and decreasing costs of high-throughput
technologies have sparked intensive research into tumour–immune cell interactions using …

Advances in high-throughput sequencing technologies now allow for large-scale
characterization of B cell immunoglobulin (Ig) repertoires. The high germline and somatic …

The variable domain of an immunoglobulin (IG) sequence is encoded by multiple genes,
including the variable (V) gene, the diversity (D) gene and the joining (J) gene. Analysis of …

Abstract IMGT/V-QUEST is the highly customized and integrated system for the standardized
analysis of the immunoglobulin (IG) and T cell receptor (TR) rearranged nucleotide …

Driven by dramatic technological improvements, large-scale characterization of lymphocyte
receptor repertoires via high-throughput sequencing is now feasible. Although promising …

High-throughput sequencing of B-cell immunoglobulin repertoires is increasingly being
applied to gain insights into the adaptive immune response in healthy individuals and in …

Abstract Background The Immunoglobulins (IG) and the T cell receptors (TR) play the key
role in antigen recognition during the adaptive immune response. Recent progress in next …

B cells produce a diverse antibody repertoire by undergoing gene rearrangements.
Pathogen exposure induces the clonal expansion of B cells expressing antibodies that can …

Dengue is the most prevalent mosquito-borne viral disease in humans, and the lack of early
prognostics, vaccines, and therapeutics contributes to immense disease burden. To identify …