Retinal degeneration and Alzheimer's disease: an evolving link

A Ashok, N Singh, S Chaudhary… - International journal of …, 2020 - mdpi.com
Age-related macular degeneration (AMD) and glaucoma are degenerative conditions of the
retina and a significant cause of irreversible blindness in developed countries. Alzheimer's …

Potential therapeutic candidates for age-related macular degeneration (AMD)

S Nashine - Cells, 2021 - mdpi.com
Aging contributes to the risk of development of ocular diseases including, but not limited to,
Age-related Macular Degeneration (AMD) that is a leading cause of blindness in the United …

[HTML][HTML] Amyloid-beta and tau protein beyond Alzheimer's disease

M Abyadeh, V Gupta, JA Paulo… - Neural Regeneration …, 2024 - journals.lww.com
The aggregation of amyloid-beta peptide and tau protein dysregulation are implicated to
play key roles in Alzheimer's disease pathogenesis and are considered the main …

Role of retinal amyloid-β in neurodegenerative diseases: overlapping mechanisms and emerging clinical applications

L Wang, X Mao - International journal of molecular sciences, 2021 - mdpi.com
Amyloid-β (Aβ) accumulations have been identified in the retina for neurodegeneration-
associated disorders like Alzheimer's disease (AD), glaucoma, and age-related macular …

Interactions between apolipoprotein E metabolism and retinal inflammation in age-related macular degeneration

ML Hu, J Quinn, K Xue - Life, 2021 - mdpi.com
Age-related macular degeneration (AMD) is a multifactorial retinal disorder that is a major
global cause of severe visual impairment. The development of an effective therapy to treat …

Age-related macular degeneration and neurodegenerative disorders: Shared pathways in complex interactions

S Jabbehdari, AC Oganov, F Rezagholi… - Survey of …, 2024 - Elsevier
Age-related macular degeneration (AMD) is a leading cause of irreversible blindness in the
elderly, and neurodegenerative disorders such as Alzheimer disease and Parkinson …

Neutrophils homing into the retina trigger pathology in early age-related macular degeneration

S Ghosh, A Padmanabhan, T Vaidya… - Communications …, 2019 - nature.com
Age-related macular degeneration (AMD) is an expanding problem as longevity increases
worldwide. While inflammation clearly contributes to vision loss in AMD, the mechanism …

Elovanoids counteract oligomeric β-amyloid-induced gene expression and protect photoreceptors

KV Do, MAI Kautzmann, B Jun… - Proceedings of the …, 2019 - National Acad Sciences
The onset of neurodegenerative diseases activates inflammation that leads to progressive
neuronal cell death and impairments in cognition (Alzheimer's disease) and sight (age …

Cytoprotective potential of fucoxanthin in oxidative stress-induced age-related macular degeneration and retinal pigment epithelial cell senescence in vivo and in vitro

SJ Chen, TB Lin, HY Peng, HJ Liu, AS Lee, CH Lin… - Marine Drugs, 2021 - mdpi.com
Oxidative stress is identified as a major inducer of retinal pigment epithelium (RPE) cell
dysregulation and is associated with age-related macular degeneration (AMD). The …

Alzheimer disease treatment with acetylcholinesterase inhibitors and incident age-related macular degeneration

SS Sutton, J Magagnoli, TH Cummings… - JAMA …, 2024 - jamanetwork.com
Importance Age-related macular degeneration (AMD) is a serious and common
ophthalmologic disorder that is hypothesized to result, in part, from inflammatory reactions in …