Privileged structures have been widely used as an effective template for the research and
discovery of high value chemicals. Coumarin is a simple scaffold widespread in Nature and …

Cancer is the second leading cause of death worldwide, and it results in around 9 million
deaths annually. The anticancer agents play an intriguing role in the treatment of cancers …

Positron emission tomography with selective radioligands advances the drug discovery and
development process by revealing information about target engagement, proof of …

In this work, different series of benzothiazole-based sulphonamides 8a-c, 10, 12, 16a-b and
carboxylic acids 14a-c were developed as novel SLC-0111 analogues with the goal of …

Biologically active compounds play a key role in the fight against diseases affecting both
human and animal living organisms, as well as plants. Finding out about new molecules …

Chemotherapy is an important therapeutic approach for the treatment of cancer. Currently,
many anticancer drugs are available in the market that plays an important role in cancer …

Coumarins and their derivatives are receiving increasing attention due to numerous
biochemical and pharmacological applications. In this study, a series of novel coumarin–1 …

Many researchers around the world are working on the development of novel anticancer
drugs with different mechanisms of action. In this case, coumarin is a highly promising …

In this study, a series of 1, 3, 4-oxadiazole derivatives (5a-s, 10a-s, and 16a-d) were
designed and synthesized using maximal electroshock (MES) and subcutaneous …

Thymidylate synthase (TS) has been an attention-grabbing area of research for the
treatment of cancers due to their role in DNA biosynthesis. In the present study, we have …