Colorectal cancer (CRC) is one of the most frequently occurring malignancy tumors with a
high morbidity additionally, CRC patients may develop liver metastasis, which is the major …

Neutrophil extracellular traps (NET) are the extracellular release of decondensed chromatin
and granules known for their role in host defense against foreign pathogens. However, a …

Colorectal cancer (CRC) is the third most common and the second most fatal cancer. In
recent years, more attention has been directed toward the role of gut microbiota in the …

Intrahepatic cholangiocarcinoma (iCCA) exhibits extensive intratumoral heterogeneity and
an extremely high mortality rate. Here, we performed whole-exome sequencing, RNA …

RAS and MYC rank amongst the most commonly altered oncogenes in cancer, with RAS
being the most frequently mutated and MYC the most amplified. The cooperative interplay …

While the field of precision oncology is rapidly expanding and more targeted options are
revolutionizing cancer treatment paradigms, therapeutic resistance particularly to …

Neutrophils form sticky web-like structures known as neutrophil extracellular traps (NETs) as
part of innate immune response. NETs are decondensed extracellular chromatin filaments …

In humans, Interleukin-8 (IL-8 or CXCL8) is a granulocytic chemokine with multiple roles
within the tumor microenvironment (TME), such as recruiting immunosuppressive cells to the …

Simple Summary Tumor-associated neutrophils (TANs) may differentiate into different
patterns under the stimulation of different factors, and they play a dual role in the occurrence …

RAS genes are the most frequently mutated oncogenes in cancer. These mutations occur in
roughly half of the patients with colorectal cancer (CRC). RAS mutant tumors are resistant to …