Mitochondria are critical multifunctional organelles in cells that generate power, produce
reactive oxygen species, and regulate cell survival. Mitochondria that are dysfunctional are …

Phototherapy, which relies on light to trigger phototherapeutic agents (PAs) to generate
cytotoxic reactive oxygen species or hyperthermia, has received much attention in cancer …

Mitochondrion is a multifunctional organelle in a cell, and it is one of the important targets of
antitumor therapy. Conventional mitochondrial targeting strategies can hardly distinguish the …

The development of boron agents with integrated functionality, including biocompatibility,
high boron content, and cancer cell targeting, is desired to exploit the therapeutic efficacy of …

Phenazine-2, 3-diol-based dyes, KY-1Na and KY-2Na bearing one and two carboxylic acid
sodium salts, respectively, have been newly developed as water-soluble photosensitizers …

Photodynamic therapy (PDT) is an emerging treatment modality that utilizes light-sensitive
compounds, known as photosensitizers, to produce reactive oxygen species (ROS) that can …

Over the last decade, the convergence of advanced materials and innovative applications
has fostered notable scientific progress within the biomedical and pharmaceutical fields …

Boron neutron capture therapy (BNCT) is a promising modality for cancer treatment because
of its minimal invasiveness. To maximize the therapeutic benefits of BNCT, the development …

To address problems in drug discovery, we developed approaches to solubilize
hydrophobic compounds using polypeptides including poly-L-lysine (PLL) via high-speed …

The electronic absorption and vibrational spectra of deprotonated 5, 10, 15, 20-tetrakis (p-
hydroxyphenyl) porphyrin (THPP) are studied as a function of solvent polarity in H2O-DMF …