The 3D organization of mammalian chromatin was described more than 30 years ago by
visualizing sites of DNA synthesis at different times during the S phase of the cell cycle …

Successful genome duplication is required for cell proliferation and demands extraordinary
precision and accuracy. The mechanisms by which cells enter, progress through, and exit S …

Complete genome duplication is essential for genetic homeostasis over successive cell
generations. Higher eukaryotes possess a complex genome replication program that …

DNA replication is spatially and temporally regulated during S phase to execute efficient and
coordinated duplication of entire genome. Various epigenomic mechanisms operate to …

In eukaryotes, DNA replication progresses through a finely orchestrated temporal and
spatial program. The 3D genome structure and nuclear architecture have recently emerged …

Efficient replication of terminal DNA is crucial to maintain telomere stability. In fission yeast,
Taz1 and the Stn1-Ten1 (ST) complex play prominent roles in DNA-ends replication …

In mammalian cells, DNA replication timing is controlled at the level of megabase (Mb)-sized
chromosomal domains and correlates well with transcription, chromatin structure, and three …

Telomeres arose from the need to stabilize natural chromosome ends, resulting in terminal
chromatin structures with specific protective functions. Their constituent proteins also …

Telomeres consist of repetitive tracts of DNA that shield a chromosome's contents from
erosion and replicative attrition. However, telomeres are also late-replicating regions of the …

In mammalian cells, chromosomal replication starts at thousands of origins at which
replisomes are assembled and bidirectional DNA synthesis is established. The slowdown of …