Human aging is currently defined as a physiological decline of biological functions in the
body with a continual adaptation to internal and external damaging. The endocrine system …

We assembled a collection of 28,297 participants from seven studies of longevity and
healthy aging comprising New England Centenarian, Long Life Family, Longevity Gene …

We use a genome-wide association of 1 million parental lifespans of genotyped subjects
and data on mortality risk factors to validate previously unreplicated findings near CDKN2B …

Because people age differently, age is not a sufficient marker of susceptibility to disabilities,
morbidities, and mortality. We measured nineteen blood biomarkers that include …

Psychiatry and Psychosomatic Medicine are concerned with medical conditions affecting
brain, mind and behaviour in manifold ways. Traditional approaches have focused on a …

The search for the genetic determinants of extreme human longevity has been challenged
by the phenotype's rarity and its nonspecific definition by investigators. To address these …

Abstract The NIA Long Life Family Study (LLFS) is a longitudinal, multicenter, multinational,
population-based multigenerational family study of the genetic and nongenetic determinants …

Objectives To determine, in a sample of Ashkenazi Jewish aged 95 and older, whether there
is a compression of morbidity similar to what has been reported in other cohorts with …

Using samples from the New England Centenarian Study (NECS), we sought to characterize
the serum proteome of 77 centenarians, 82 centenarians' offspring, and 65 age‐matched …

Although many genetic factors and lifestyle interventions are known to affect the mean
lifespan of animal populations, the physiological variation displayed by individuals across …