[HTML][HTML] Dietary regulation in health and disease

Q Wu, ZJ Gao, X Yu, P Wang - Signal Transduction and Targeted …, 2022 - nature.com
Nutriments have been deemed to impact all physiopathologic processes. Recent evidences
in molecular medicine and clinical trials have demonstrated that adequate nutrition …

[HTML][HTML] Mechanisms of systemic osmoregulation in insects

KV Halberg, B Denholm - Annual Review of Entomology, 2024 - annualreviews.org
Water is essential to life. Terrestrial insects lose water by evaporation from the body surface
and respiratory surfaces, as well as in the excretory products, posing a challenge made …

[HTML][HTML] A gut-derived hormone suppresses sugar appetite and regulates food choice in Drosophila

A Malita, O Kubrak, T Koyama, N Ahrentløv… - Nature …, 2022 - nature.com
Animals must adapt their dietary choices to meet their nutritional needs. How these needs
are detected and translated into nutrient-specific appetites that drive food-choice behaviours …

NHA1 is a cation/proton antiporter essential for the water-conserving functions of the rectal complex in Tribolium castaneum

MT Naseem, R Beaven, T Koyama… - Proceedings of the …, 2023 - National Acad Sciences
More than half of all extant metazoan species on earth are insects. The evolutionary success
of insects is linked with their ability to osmoregulate, suggesting that they have evolved …

[HTML][HTML] The gut hormone Allatostatin C/Somatostatin regulates food intake and metabolic homeostasis under nutrient stress

O Kubrak, T Koyama, N Ahrentløv, L Jensen… - Nature …, 2022 - nature.com
The intestine is a central regulator of metabolic homeostasis. Dietary inputs are absorbed
through the gut, which senses their nutritional value and relays hormonal information to …

[HTML][HTML] FoxO directly regulates the expression of odorant receptor genes to govern olfactory plasticity upon starvation in Bactrocera dorsalis

Y Chen, B Hong, Y Zhang, X Chen, T Zhang… - Insect Biochemistry and …, 2023 - Elsevier
Under nutrient-poor conditions, animals must save energy by adjusting their behavior and
physiology in order to survive. Although the impact of feeding state on olfactory sensory …

[HTML][HTML] A neuroendocrine pathway modulating osmotic stress in Drosophila

M Zandawala, T Nguyen, M Balanyà Segura… - PLoS …, 2021 - journals.plos.org
Environmental factors challenge the physiological homeostasis in animals, thereby evoking
stress responses. Various mechanisms have evolved to counter stress at the organism level …

[HTML][HTML] A nutrient responsive lipase mediates gut-brain communication to regulate insulin secretion in Drosophila

A Singh, KV Abhilasha, KR Acharya, H Liu… - Nature …, 2024 - nature.com
Pancreatic β cells secrete insulin in response to glucose elevation to maintain glucose
homeostasis. A complex network of inter-organ communication operates to modulate insulin …

[HTML][HTML] LGR signaling mediates muscle-adipose tissue crosstalk and protects against diet-induced insulin resistance

O Kubrak, AF Jørgensen, T Koyama, M Lassen… - Nature …, 2024 - nature.com
Obesity impairs tissue insulin sensitivity and signaling, promoting type-2 diabetes. Although
improving insulin signaling is key to reversing diabetes, the multi-organ mechanisms …

[HTML][HTML] Compensatory enhancement of input maintains aversive dopaminergic reinforcement in hungry Drosophila

E Meschi, L Duquenoy, N Otto, G Dempsey, S Waddell - Neuron, 2024 - cell.com
Hungry animals need compensatory mechanisms to maintain flexible brain function, while
modulation reconfigures circuits to prioritize resource seeking. In Drosophila, hunger inhibits …