Alignment-free sequence comparison: benefits, applications, and tools

A Zielezinski, S Vinga, J Almeida, WM Karlowski - Genome biology, 2017 - Springer
Alignment-free sequence analyses have been applied to problems ranging from whole-
genome phylogeny to the classification of protein families, identification of horizontally …

Genomic signatures of high-altitude adaptation and chromosomal polymorphism in geladas

KL Chiou, MC Janiak, IA Schneider-Crease… - Nature ecology & …, 2022 - nature.com
Primates have adapted to numerous environments and lifestyles but very few species are
native to high elevations. Here we investigated high-altitude adaptations in the gelada …

Alignment-based and alignment-free methods converge with experimental data on amino acids coded by stop codons at split between nuclear and mitochondrial …

H Seligmann - Biosystems, 2018 - Elsevier
Genetic codes mainly evolve by reassigning punctuation codons, starts and stops. Previous
analyses assuming that undefined amino acids translate stops showed greater divergence …

A survey on data compression methods for biological sequences

M Hosseini, D Pratas, AJ Pinho - Information, 2016 - mdpi.com
The ever increasing growth of the production of high-throughput sequencing data poses a
serious challenge to the storage, processing and transmission of these data. As frequently …

The domestication of Cucurbita argyrosperma as revealed by the genome of its wild relative

J Barrera-Redondo, G Sanchez-de La Vega… - Horticulture …, 2021 - academic.oup.com
Despite their economic importance and well-characterized domestication syndrome, the
genomic impact of domestication and the identification of variants underlying the …

Efficient DNA sequence compression with neural networks

M Silva, D Pratas, AJ Pinho - GigaScience, 2020 - academic.oup.com
Background The increasing production of genomic data has led to an intensified need for
models that can cope efficiently with the lossless compression of DNA sequences. Important …

New insights into mammalian sex chromosome structure and evolution using high-quality sequences from bovine X and Y chromosomes

R Liu, WY Low, R Tearle, S Koren, J Ghurye, A Rhie… - BMC genomics, 2019 - Springer
Background Mammalian X chromosomes are mainly euchromatic with a similar size and
structure among species whereas Y chromosomes are smaller, have undergone substantial …

K-mer Content, Correlation, and Position Analysis of Genome DNA Sequences for the Identification of Function and Evolutionary Features

A Sievers, K Bosiek, M Bisch, C Dreessen, J Riedel… - Genes, 2017 - mdpi.com
In genome analysis, k-mer-based comparison methods have become standard tools.
However, even though they are able to deliver reliable results, other algorithms seem to …

Functionality of Two Origins of Replication in Vibrio cholerae Strains With a Single Chromosome

M Bruhn, D Schindler, FS Kemter, MR Wiley… - Frontiers in …, 2018 - frontiersin.org
Chromosomal inheritance in bacteria usually entails bidirectional replication of a single
chromosome from a single origin into two copies and subsequent partitioning of one copy …

Smash++: an alignment-free and memory-efficient tool to find genomic rearrangements

M Hosseini, D Pratas, B Morgenstern, AJ Pinho - Gigascience, 2020 - academic.oup.com
Background The development of high-throughput sequencing technologies and, as its
result, the production of huge volumes of genomic data, has accelerated biological and …