Great progress has been made in recent years to reduce the high level of suffering caused
by malaria worldwide. Notably, the use of insecticide-treated mosquito nets for malaria …

Malaria has been a major global health problem of humans through history and is a leading
cause of death and disease across many tropical and subtropical countries. Over the last …

Fluorine-containing amino acids are becoming increasingly prominent in new drugs due to
two general trends in the modern pharmaceutical industry. Firstly, the growing acceptance of …

Despite substantial scientific progress over the past two decades, malaria remains a
worldwide burden that causes hundreds of thousands of deaths every year. New, affordable …

The last two decades have seen a surge in antimalarial drug development with product
development partnerships taking a leading role. Resistance of Plasmodium falciparum to the …

Diverse compounds target the Plasmodium falciparum Na+ pump PfATP4, with cipargamin
and (+)-SJ733 the most clinically-advanced. In a recent clinical trial for cipargamin …

The intraerythrocytic malaria parasite, Plasmodium falciparum, maintains a low cytosolic
Na+ concentration and the plasma membrane P-type cation translocating ATPase …

Malaria is a devastating disease caused by Plasmodium parasites, resulting in
approximately 435000 deaths in 2018. The impact of malaria is compounded by the …

Objective: The spirooxindole heterocyclic scaffold is found in many natural products and has
been identified as an important bioactive agent. Background: Over the past few decades …

The emergence of drug-resistant malaria parasites continues to hamper efforts to control this
lethal disease. Dihydroorotate dehydrogenase has recently been validated as a new target …