The tumour microenvironment and metabolism in renal cell carcinoma targeted or immune therapy

Y Lai, F Tang, Y Huang, C He, C Chen… - Journal of cellular …, 2021 - Wiley Online Library
Renal cell carcinoma (RCC) is one of the most common tumours of the urinary system, and
is insidious and not susceptible to chemoradiotherapy. As the most common subtype of RCC …

Shaping up the tumor microenvironment with cellular fibronectin

G Efthymiou, A Saint, M Ruff, Z Rekad, D Ciais… - Frontiers in …, 2020 - frontiersin.org
Normal tissue homeostasis and architecture restrain tumor growth. Thus, for a tumor to
develop and spread, malignant cells must overcome growth-repressive inputs from …

Fibronectin regulates anoikis resistance via cell aggregate formation

H Han, JY Sung, SH Kim, UJ Yun, H Kim, EJ Jang… - Cancer letters, 2021 - Elsevier
The loss of cell-matrix interactions induces apoptosis, known as anoikis. For successful
distant metastasis, circulating tumor cells (CTCs) that have lost matrix attachment need to …

Grapefruit-derived extracellular vesicles as a promising cell-free therapeutic tool for wound healing

Y Savcı, OK Kırbaş, BT Bozkurt, EA Abdik, PN Taşlı… - Food & Function, 2021 - pubs.rsc.org
Due to the prevalence of individuals suffering from chronic wounds, developing safe and
effective wound care agents are one of the more prominent fields of research in biology …

Anticancer activity of rutin and its combination with ionic liquids on renal cells

R Caparica, A Júlio, MEM Araújo, AR Baby, P Fonte… - Biomolecules, 2020 - mdpi.com
The renal cell carcinoma (RCC) is the most common type of kidney cancer. Identifying novel
and more effective therapies, while minimizing toxicity, continues to be fundamental in …

The functional role of extracellular matrix proteins in cancer

NV Popova, M Jücker - Cancers, 2022 - mdpi.com
Simple Summary Extracellular matrix is a three-dimensional network of macromolecules that
provide structural and biochemical support to surrounding cells. Extracellular matrix plays a …

[HTML][HTML] MicroRNA-196a promotes renal cancer cell migration and invasion by targeting BRAM1 to regulate SMAD and MAPK signaling pathways

J Cui, Y Yuan, MK Shanmugam… - … Journal of Biological …, 2021 - ncbi.nlm.nih.gov
Rationale: MicroRNAs (miRNAs) are endogenous~ 22nt RNAs that play critical regulatory
roles in various biological and pathological processes, including various cancers. Their …

Targeting strategies in the treatment of fumarate hydratase deficient renal cell carcinoma

AK Lindner, G Tulchiner, A Seeber, PJ Siska… - Frontiers in …, 2022 - frontiersin.org
Fumarate hydratase (FH)-deficient renal cell carcinoma (FHdRCC) is a rare aggressive
subtype of RCC caused by a germline or sporadic loss-of-function mutation in the FH gene …

Nanomedicine Strategies for Targeting Tumor Stroma

MC Su, SK Nethi, PK Dhanyamraju, S Prabha - Cancers, 2023 - mdpi.com
Simple Summary The tumor microenvironment plays an important role in drug resistance
and supports/promotes tumorigenesis. Stromal modulators in combination with …

Fibronectin enhances tumor metastasis through B7‐H3 in clear cell renal cell carcinoma

J Xie, M Sun, D Zhang, C Chen, S Lin… - FEBS Open Bio, 2021 - Wiley Online Library
B7 homolog 3 (B7‐H3) plays an important role in tumor biology, but the molecular
mechanism underlying the role of B7‐H3 in tumor metastasis remains unclear. In this article …