Pre-eclampsia is a severe pregnant complication, mainly characterized by insufficient
trophoblast invasion, impaired uterine spiral artery remodeling, placental hypoxia and …

Sirtuins, especially SIRT1, play a significant role in regulating inflammatory response,
autophagy, and cell response to oxidative stress. Since their discovery, sirtuins have been …

Introduction Premature placental aging is implicated in a number of complications of
pregnancy including preeclampsia. A placenta knockout mouse model has shown a …

Background: Selenium and coenzyme Q10 (SeQ10) possess antioxidant and anti-
inflammatory properties, potentially mediated via Sirtuin1 (SIRT1). We aimed to investigate …

Background and Purpose Preeclampsia, characterized by hypertension, proteinuria and
restriction of fetal growth, is one of the leading causes of maternal and perinatal mortality. So …

Preeclampsia (PE) is a multifactorial hypertensive disorder of pregnancy that is partly
responsible for both maternal and fetal morbidity and mortality levels worldwide. It has been …

Hypertensive disorders of pregnancy are complications that can lead to maternal and infant
mortality and morbidity. Hypertensive disorders of pregnancy are generally defined as …

Hypertension can be induced by the disruption of factors in blood pressure regulation. This
includes several systems such as Neurohumoral, Renin-angiotensin-aldosterone, the …

In brief Preeclampsia (PE) is a severe complication that leads to major maternal and fetal
mortality and morbidity, and one of its causes is extravillous trophoblast (EVT) dysfunction …

Objective To explore the role of silent information regulator 1 (SIRT1)-mediated Sonic
Hedgehog (SHH) pathway in reduced uterine perfusion pressure (RUPP) model of …