Cellular stress is an intrinsic part of cell physiology that underlines cell survival or death. The
ability of mammalian cells to regulate global protein synthesis (aka translational control) …

It has recently become clear that ribosomes are much more heterogeneous than previously
thought, with diversity arising from rRNA sequence and modifications, ribosomal protein …

Cells maintain reserves in their metabolic and translational capacities as a strategy to
quickly respond to changing environments. Here we quantify these reserves by stepwise …

Although ribosome assembly is quality controlled to maintain protein homeostasis, different
ribosome populations have been described. How these form, especially under stress …

Ribosomes are often seen as monolithic machines produced from uniformly regulated
genes. However, in yeast most ribosomal proteins come from duplicated genes. Here, we …

Summary mRNA translation is a highly conserved and tightly controlled mechanism for
protein synthesis and is well known to be altered by oncogenes to promote cancer …

Abstract Ribosomes of Bacteroidia (formerly Bacteroidetes) fail to recognize Shine-Dalgarno
(SD) sequences even though they harbor the anti-SD (ASD) of 16S rRNA. Inhibition of SD …

Glucose is one of the most important sources of carbon across all life. Glucose starvation is a
key stress relevant to all eukaryotic cells. Glucose starvation responses have important …

Premature release of nascent ribosomes into the translating pool must be prevented
because these do not support viability and may be prone to mistakes. Here, we show that …

Post-transcriptional ribosomal RNA (rRNA) modifications are present in all organisms, but
their exact functional roles and positions are yet to be fully characterized. Modified …