Application of biological domain knowledge based feature selection on gene expression data

M Yousef, A Kumar, B Bakir-Gungor - Entropy, 2020 - mdpi.com
In the last two decades, there have been massive advancements in high throughput
technologies, which resulted in the exponential growth of public repositories of gene …

Review of feature selection approaches based on grouping of features

C Kuzudisli, B Bakir-Gungor, N Bulut, B Qaqish… - PeerJ, 2023 - peerj.com
With the rapid development in technology, large amounts of high-dimensional data have
been generated. This high dimensionality including redundancy and irrelevancy poses a …

Inflammatory bowel disease biomarkers of human gut microbiota selected via different feature selection methods

B Bakir-Gungor, H Hacılar, A Jabeer, OU Nalbantoglu… - PeerJ, 2022 - peerj.com
The tremendous boost in next generation sequencing and in the “omics” technologies
makes it possible to characterize the human gut microbiome—the collective genomes of the …

GediNET for discovering gene associations across diseases using knowledge based machine learning approach

E Qumsiyeh, L Showe, M Yousef - Scientific reports, 2022 - nature.com
The most common approaches to discovering genes associated with specific diseases are
based on machine learning and use a variety of feature selection techniques to identify …

TextNetTopics: text classification based word grouping as topics and topics' scoring

M Yousef, D Voskergian - Frontiers in Genetics, 2022 - frontiersin.org
Medical document classification is one of the active research problems and the most
challenging within the text classification domain. Medical datasets often contain massive …

PriPath: identifying dysregulated pathways from differential gene expression via grouping, scoring, and modeling with an embedded feature selection approach

M Yousef, F Ozdemir, A Jaber, J Allmer… - BMC …, 2023 - Springer
Background Cell homeostasis relies on the concerted actions of genes, and dysregulated
genes can lead to diseases. In living organisms, genes or their products do not act alone but …

Prediction of linear cationic antimicrobial peptides active against gram-negative and gram-positive bacteria based on machine learning models

ÜG Söylemez, M Yousef, Z Kesmen, ME Büyükkiraz… - Applied Sciences, 2022 - mdpi.com
Antimicrobial peptides (AMPs) are considered as promising alternatives to conventional
antibiotics in order to overcome the growing problems of antibiotic resistance …

miRdisNET: discovering microRNA biomarkers that are associated with diseases utilizing biological knowledge-based machine learning

A Jabeer, M Temiz, B Bakir-Gungor, M Yousef - Frontiers in Genetics, 2023 - frontiersin.org
During recent years, biological experiments and increasing evidence have shown that
microRNAs play an important role in the diagnosis and treatment of human complex …

miRModuleNet: detecting miRNA-mRNA regulatory modules

M Yousef, G Goy, B Bakir-Gungor - Frontiers in Genetics, 2022 - frontiersin.org
Increasing evidence that microRNAs (miRNAs) play a key role in carcinogenesis has
revealed the need for elucidating the mechanisms of miRNA regulation and the roles of …

miRcorrNet: machine learning-based integration of miRNA and mRNA expression profiles, combined with feature grouping and ranking

M Yousef, G Goy, R Mitra, CM Eischen, A Jabeer… - PeerJ, 2021 - peerj.com
A better understanding of disease development and progression mechanisms at the
molecular level is critical both for the diagnosis of a disease and for the development of …