Sjögren's syndrome is a chronic autoimmune disease characterized by ocular and oral
dryness resulting from lacrimal and salivary gland dysfunction. Besides, a variety of systemic …

In primary Sjögren syndrome (pSS), the function of the salivary glands is often considerably
reduced. Multiple innate immune pathways are likely dysregulated in the salivary gland …

Primary Sjögren's syndrome (pSS) is a prototypic autoimmune disorder, management of
which has long suffered from a lack of knowledge of the underlying pathophysiological …

Gene expression analysis of target organs might help provide new insights into the
pathogenesis of autoimmune diseases. We used global gene expression profiling of minor …

Objective. To investigate functional properties of the germinal center (GC)–like structures
observed in salivary glands of patients with Sjögren's syndrome (SS) and to determine the …

Background Mass cytometry has recently emerged as a promising tool for clinical research.
However, few studies have demonstrated its benefit for patient stratification and biomarker …

Objective Primary Sjögren's syndrome (pSS) is characterised by chronic hyperactivation of B
lymphocytes. Salivary gland epithelial cells (SGECs) could play a role in promoting B …

Sjögren's syndrome (SS), a chronic autoimmune disorder, particularly compromises the
function of exocrine glands. The involvement of these glands is characterized by focal …

B cell-activating factor (BAFF) has a key role in promoting B-lymphocyte activation and
survival in primary Sjögren's syndrome (pSS). The cellular origin of BAFF overexpression in …

A histologic hallmark of primary SS (pSS) is lymphocytic infiltration of the salivary and
lacrimal glands, in particular by CD4+ T and B cells. In the early stages of the disease …