Malaria has been the pre-eminent cause of early mortality in many parts of the world
throughout much of the last five thousand years and, as a result, it is the strongest force for …

Significant selection pressure has been exerted on the genomes of human populations
exposed to Plasmodium falciparum infection, resulting in the acquisition of mechanisms of …

Malaria is a life-threatening blood disease caused by the protozoan Plasmodium. Infection
may lead to several different patterns of symptoms in the host: asymptomatic state …

Abstract Background In Plasmodium falciparum infection, clinical conditions such as
anaemia, thrombocytopenia and leukocytosis are common. Mutation in haemoglobin sub …

Background Severe malarial anaemia (SMA) is a leading cause of childhood mortality in
holoendemic Plasmodium falciparum regions. Methods To gain an improved understanding …

Background: Severe malarial anemia (SMA; Hb< 5.0 g/dl) is a leading cause of childhood
morbidity and mortality in holoendemic Plasmodium falciparum transmission regions such …

Background Leukocyte-associated immunoglobulin like receptor-1 (LAIR1) is a
transmembrane inhibitory receptor that influences susceptibility to a myriad of inflammatory …

Background Emerging evidence suggests that the interleukin (IL) 17/IL-23 axis may play a
role in the pathogenesis of leishmaniasis. Our aim was to investigate whether the IL-23R …

ABSTRACT The Fcγ receptor IIIb (FcγRIIIb) is a low-affinity receptor of IgG and is essential in
neutrophil-mediated effector functions. Different allelic forms of FcγRIIIb carrying human …

Background Cerebral malaria (CM) is a preeminent cause of severe disease and premature
deaths in Sub-Saharan Africa, where an estimated 90% of cases occur. The key features of …