Drugs with low water solubility are predisposed to low and variable oral bioavailability and,
therefore, to variability in clinical response. Despite significant efforts to “design in” …

Lipid-based drug delivery systems (LBDDS) are one of the most studied bioavailability
enhancement technologies and are utilized in a number of US Food and Drug …

Lipid-based delivery systems are finding increasing application in the oral delivery of poorly
water-soluble, lipophilic drugs. Whilst lipidic dose forms may improve oral bioavailability via …

The purpose of this study was to develop mesoporous silica nanoparticles (MSNs) loaded
with a poorly water-soluble drug, intended to be orally administered, able to improve the …

Cryptococcal meningitis is the leading cause of adult meningitis in sub-Saharan Africa, and
contributes up to 20% of AIDS-related mortality in low-income and middle-income countries …

Amphotericin B (AmB) loaded polymer lipid hybrid nanoparticles (AmB-PLNs) comprised of
lecithin (anionic lipid) and gelatin (Type A, cationic below its isoelectric point 7.0–9.0) were …

The oral route for delivery of pharmaceuticals is the most widely used and accepted.
Nanoparticles and microparticles are increasingly being applied within this arena to …

Amphotericin B (AMB) is used most commonly in severe systemic life-threatening fungal
infections. There is currently an unmet need for an efficacious (AMB) formulation amenable …

Amphotericin B (AmB) remains the “gold standard” for systemic antifungal therapy, even
though new drugs are emerging as the attractive antifungal agents. Since AmB has …

Pumps of the ATP-binding cassette superfamily (ABCs) regulate the access of drugs to the
intracellular space. In this context, the overexpression of ABCs is a well-known mechanism …