A new era in posterior segment ocular drug delivery: Translation of systemic, cell-targeted, dendrimer-based therapies
Vision impairment and loss due to posterior segment ocular disorders, including age-related
macular degeneration and diabetic retinopathy, are a rapidly growing cause of disability …
macular degeneration and diabetic retinopathy, are a rapidly growing cause of disability …
[HTML][HTML] Dendrimers and derivatives as multifunctional nanotherapeutics for Alzheimer's disease
DA Moreira, SD Santos, V Leiro, AP Pêgo - Pharmaceutics, 2023 - mdpi.com
Alzheimer's disease (AD) is the most prevalent form of dementia. It affects more than 30
million people worldwide and costs over US $1.3 trillion annually. AD is characterized by the …
million people worldwide and costs over US $1.3 trillion annually. AD is characterized by the …
[HTML][HTML] Targeting mitochondrial dysfunction and oxidative stress in activated microglia using dendrimer-based therapeutics
Mitochondrial oxidative stress is associated with many neurodegenerative diseases, such as
traumatic brain injury (TBI). Targeted delivery of antioxidants to mitochondria has failed to …
traumatic brain injury (TBI). Targeted delivery of antioxidants to mitochondria has failed to …
Glycosylation of PAMAM dendrimers significantly improves tumor macrophage targeting and specificity in glioblastoma
Glioblastoma is among the most aggressive forms of cancers, with a median survival of just
15–20 months for patients despite maximum clinical intervention. The majority of …
15–20 months for patients despite maximum clinical intervention. The majority of …
Effect of mannose targeting of hydroxyl PAMAM dendrimers on cellular and organ biodistribution in a neonatal brain injury model
Neurotherapeutics for the treatment of central nervous system (CNS) disorders must
overcome challenges relating to the blood-brain barrier (BBB), brain tissue penetration, and …
overcome challenges relating to the blood-brain barrier (BBB), brain tissue penetration, and …
Targeted microglial attenuation through Dendrimer–drug conjugates improves Glaucoma neuroprotection
Retinal microglial/macrophage activation and optic nerve (ON) microglial/macrophage
activation are glaucoma biomarkers and potential therapeutic targets for this blinding …
activation are glaucoma biomarkers and potential therapeutic targets for this blinding …
Systemic dendrimer delivery of triptolide to tumor-associated macrophages improves anti-tumor efficacy and reduces systemic toxicity in glioblastoma
Novel delivery strategies are necessary to effectively address glioblastoma without systemic
toxicities. Triptolide is a therapy derived from the thunder god vine that has shown potent …
toxicities. Triptolide is a therapy derived from the thunder god vine that has shown potent …
Ordered polypyrrole nanorings with near-infrared spectrum absorption and photothermal conversion performance
G Qin, J Qiu - Chemical Engineering Journal, 2019 - Elsevier
Abstract Ordered polypyrrole nanorings (PPy NRs) morphology is synthesized by direct
chemical oxidative polymerization using the composite of cetrimonium cations and …
chemical oxidative polymerization using the composite of cetrimonium cations and …
Targeting mitochondria in tumor-associated macrophages using a dendrimer-conjugated TSPO ligand that stimulates antitumor signaling in glioblastoma
Mitochondria mediate critical cellular processes, including proliferation, apoptosis, and
immune responses; as such, their dysfunction is pathogenic in many neurodegenerative …
immune responses; as such, their dysfunction is pathogenic in many neurodegenerative …
Targeted systemic dendrimer delivery of CSF‐1R inhibitor to tumor‐associated macrophages improves outcomes in orthotopic glioblastoma
Glioblastoma is the most common and aggressive form of primary brain cancer, with median
survival of 16–20 months and a 5‐year survival rates of< 5%. Recent advances in …
survival of 16–20 months and a 5‐year survival rates of< 5%. Recent advances in …