Exploring the potential of cell-derived vesicles for transient delivery of gene editing payloads
K Leandro, D Rufino-Ramos, K Breyne… - Advanced Drug Delivery …, 2024 - Elsevier
Gene editing technologies have the potential to correct genetic disorders by modifying,
inserting, or deleting specific DNA sequences or genes, paving the way for a new class of …
inserting, or deleting specific DNA sequences or genes, paving the way for a new class of …
Unlocking the therapeutic applicability of LNP-mRNA: Chemistry, formulation, and clinical strategies
X Huang, Y Ma, G Ma, Y Xia - Research, 2024 - spj.science.org
Messenger RNA (mRNA) has emerged as an innovative therapeutic modality, offering
promising avenues for the prevention and treatment of a variety of diseases. The …
promising avenues for the prevention and treatment of a variety of diseases. The …
RNA delivery systems
SN Bhatia, JE Dahlman - Proceedings of the National …, 2024 - National Acad Sciences
Between December 2020 and December 2021, COVID-19 vaccines prevented over 14
million deaths (1). Two of these vaccines were lipid nanoparticles (LNPs) formulated to carry …
million deaths (1). Two of these vaccines were lipid nanoparticles (LNPs) formulated to carry …
A Lung-Expressing mRNA Delivery Platform with Tunable Activity in Hypoxic Environments
Messenger RNA (mRNA) delivery platforms often facilitate protein expression in the liver
following intravenous injection and have been optimized for use in normally oxygenated …
following intravenous injection and have been optimized for use in normally oxygenated …
Microfluidic Platform Enables Shearless Aerosolization of Lipid Nanoparticles for mRNA Inhalation
Leveraging the extensive surface area of the lungs for gene therapy, the inhalation route
offers distinct advantages for delivery. Clinical nebulizers that employ vibrating mesh …
offers distinct advantages for delivery. Clinical nebulizers that employ vibrating mesh …
Multicomponent Synthesis of Imidazole-Based Ionizable Lipids for Highly Efficient and Spleen-Selective Messenger RNA Delivery
W Dong, Z Li, T Hou, Y Shen, Z Guo… - Journal of the …, 2024 - ACS Publications
The spleen emerges as a pivotal target for mRNA delivery, prompting a continual quest for
specialized and efficient lipid nanoparticles (LNPs) designed to enhance spleen-selective …
specialized and efficient lipid nanoparticles (LNPs) designed to enhance spleen-selective …
[HTML][HTML] Nanoparticles for RNA Therapeutics: RNA delivery systems
SN Bhatia, JE Dahlman - Proceedings of the National Academy of …, 2024 - ncbi.nlm.nih.gov
Between December 2020 and December 2021, COVID-19 vaccines prevented over 14
million deaths (1). Two of these vaccines were lipid nanoparticles (LNPs) formulated to carry …
million deaths (1). Two of these vaccines were lipid nanoparticles (LNPs) formulated to carry …
Lipid nanoparticle (LNP) mediated mRNA delivery in cardiovascular diseases: Advances in genome editing and CAR T cell therapy
S Soroudi, MR Jaafari, L Arabi - Journal of Controlled Release, 2024 - Elsevier
Cardiovascular diseases (CVDs) are the leading cause of global mortality among non-
communicable diseases. Current cardiac regeneration treatments have limitations and may …
communicable diseases. Current cardiac regeneration treatments have limitations and may …
Preformed Vesicle Approach to LNP Manufacturing Enhances Retinal mRNA Delivery
Complete encapsulation of nucleic acids by lipid‐based nanoparticles (LNPs) is often
thought to be one of the main prerequisites for successful nucleic acid delivery, as the lipid …
thought to be one of the main prerequisites for successful nucleic acid delivery, as the lipid …
Biodistribution of lipid nanoparticle, eGFP mRNA and translated protein following subcutaneous administration in mouse
Å Sandelius, H Naseer, J Lindqvist, A Wilson… - Bioanalysis, 2024 - Taylor & Francis
Aim: Increased knowledge of biodistribution and pharmacokinetics of lipid nanoparticle
(LNP)-encapsulated mRNA drug components may aid efficacy and safety evaluation …
(LNP)-encapsulated mRNA drug components may aid efficacy and safety evaluation …