Tetrahydrofolate cofactors are essential for the synthesis of purines, certain amino acids,
and thymidine. Most bacteria and plants produce these folate cofactors by de novo …

Antifolates that inhibit the key enzymes thymidylate synthase (TS) and dihydrofolate
reductase (DHFR) have found clinical utility as antitumor and antiopportunistic agents …

In this manuscript, we have reported a novel 2D fingerprint-based artificial neural network
QSAR (FANN-QSAR) method in order to effectively predict biological activities of structurally …

Pharmacophore hypotheses were developed for a series of 2, 4-diamino-5-deazapteridine
inhibitors of Mycobacterium avium complex (MAC) and human dihydrofolate reductase …

A series of eighty one 2, 4, 6-trisubstituted-1, 3, 5-triazines were synthesized and evaluated
in vitro for the growth inhibition of Mycobacterium tuberculosis H37Rv. Fifteen compounds …

A series of β-aminoacylpiperidines bearing various fused five-membered heterocyclic rings
was synthesized as dipeptidyl peptidase IV inhibitors. Potent and relatively selective …

A series of eight N4-phenylsubstituted-6-(2, 4-dichlorophenylmethyl)-7H-pyrrolo [2, 3-d]
pyrimidine-2, 4-diamines 8–15 were synthesized as vascular endothelial growth factor …

ABSTRACT A structurally diverse library of 93 lipophilic di-and tricyclic diaminopyrimidine
derivatives was tested for the ability to inhibit recombinant dihydrofolate reductase (DHFR) …

As part of a larger search for potent as well as selective inhibitors of dihydrofolate reductase
(DHFR) enzymes from opportunistic pathogens found in patients with AIDS and other …

Drug resistance generated in vitro in the protozoan parasite Toxoplasma gondii is
described. We focus on drugs that are in use in patients, that show some promise for such …