Recent drug design strategies and identification of key heterocyclic scaffolds for promising anticancer targets
Cancer, a noncommunicable disease, is the leading cause of mortality worldwide and is
anticipated to rise by 75% in the next two decades, reaching approximately 25 million cases …
anticipated to rise by 75% in the next two decades, reaching approximately 25 million cases …
Synthesis of biologically active sulfonamide-based indole analogs: a review
I Mushtaq, A Ahmed - Future Journal of Pharmaceutical Sciences, 2023 - Springer
The class of heterocyclic compounds exhibits a variety of pharmacological actions, long
employed as an active ingredient in drug design and production. Indole and its derivatives …
employed as an active ingredient in drug design and production. Indole and its derivatives …
Synthesis and characterization of N4-substituted thiosemicarbazones: DNA/BSA binding, molecular docking, anticancer activity, ADME study and computational …
V Manakkadan, J Haribabu… - Journal of Molecular …, 2023 - Elsevier
A series of thiosemicarbazones with the general formula, R− CHdouble bondN− NH− C (S)−
R 1 [R= C 6 H 5 F & R 1= C 4 H 9 NO (TL1), R= C 8 H 10 O 2 & R 1= C 4 H 9 NO (TL2), R= C …
R 1 [R= C 6 H 5 F & R 1= C 4 H 9 NO (TL1), R= C 8 H 10 O 2 & R 1= C 4 H 9 NO (TL2), R= C …
N-Indolyl diiron vinyliminium complexes exhibit antiproliferative effects in cancer cells associated with disruption of mitochondrial homeostasis, ROS scavenging, and …
G Bresciani, J Cervinka, H Kostrhunova… - Chemico-Biological …, 2023 - Elsevier
The indole scaffold has been established as a key organic moiety for developing new drugs;
on the other hand, a range of diiron bis-cyclopentadienyl complexes have recently emerged …
on the other hand, a range of diiron bis-cyclopentadienyl complexes have recently emerged …
Biomolecular Interactions and Anticancer Mechanisms of Ru (II)-Arene Complexes of Cinnamaldehyde-Derived Thiosemicarbazone Ligands: Analysis Combining In …
VN Vadakkedathu Palakkeezhillam… - ACS Applied Bio …, 2024 - ACS Publications
Our study focuses on synthesizing and exploring the potential of three N-(4) substituted
thiosemicarbazones derived from cinnamic aldehyde, alongside their Ru (II)-(η6-p …
thiosemicarbazones derived from cinnamic aldehyde, alongside their Ru (II)-(η6-p …
Effect of coordination mode of thiosemicarbazone on the biological activities of its Ru (II)-benzene complexes: Biomolecular interactions and anticancer activity via …
J Haribabu, R Arulkumar, D Mahendiran… - Inorganica Chimica …, 2024 - Elsevier
Abstract Ru (II)-benzene complexes (P1 and P2) were synthesized using a
thiosemicarbazone ligand (L1) in two different coordination modes, monodentate S and …
thiosemicarbazone ligand (L1) in two different coordination modes, monodentate S and …
In vitro cytotoxic study of synthesized Ag and Ce dual-doped α-Fe2O3 nanoparticles on NIH/3T3 and U87 cell lines
The significant potential of iron oxide nanoparticles in biomedical fields, particularly in the
delivery of anticancer drugs and in sono-chemodynamic therapy, can be attributed to their …
delivery of anticancer drugs and in sono-chemodynamic therapy, can be attributed to their …
Synthesis, Characterization, and Biological Properties of the Copper(II) Complexes with Novel Ligand: N-[4-({2-[1-(pyridin-2-yl)ethylidene]hydrazinecarbothioyl}amino …
For the first time, a thiosemicarbazone-type ligand containing a paracetamol structural unit
was synthesized. Five new coordination compounds based on copper (II) salts:[Cu (L) …
was synthesized. Five new coordination compounds based on copper (II) salts:[Cu (L) …
Fabrication of marizomib-loaded zeolitic imidazolate framework-8@ manganese dioxide for promising drug delivery system of glioma cancer cells
J Jing, Q Meng, AH Hirad, MK Ramar - Process Biochemistry, 2023 - Elsevier
Marizomib is a novel, irreversible, brain-penetrant pan-proteasome inhibitor with
encouraging findings in preclinical models and early-stage clinical trials for patients with …
encouraging findings in preclinical models and early-stage clinical trials for patients with …
Exploring benzene Ru (II) complexes of 2-subsitituted quinoline/napthyridine ligands: Synthesis, biomacromolecular binding and DFT investigations
This work reports the synthesis of 2-substituted quinoline/napthyridine ligands by a
Friedländer condensation which are employed for the synthesis of half-sandwich benzene …
Friedländer condensation which are employed for the synthesis of half-sandwich benzene …